@article{487624,
      recid = {487624},
      author = {Copeland, Robert Allen.},
      title = {Evaluation of enzyme inhibitors in drug discovery a guide  for medicinal chemists and pharmacologists / [electronic  resource] :},
      publisher = {Wiley,},
      address = {Hoboken, N.J. :},
      pages = {xxx, 538 p. :},
      year = {2013},
      abstract = {"There has been explosive growth in the hunt for new  pharmaceutically agents globally. Traditionally, this has  been the purview of the pharmaceutical industry, but today,  this effort crosses academic, government, and industry  laboratories across the world. Enzymes remain the most  valued and common of drug targets; hence, a detailed  understanding of their interactions with inhibitors is  critical to successful drug discovery. This book provides a  practical, readable, and comprehensive treatment of these  topics that allows scientists to master the art of applied  enzymology for drug discovery. The book addresses the  opportunities for inhibitor interactions with enzyme  targets arising from consideration of the catalytic  reaction mechanism; discusses how inhibitors are properly  evaluated for potency, selectivity, and mode of action,  covers the potential advantages and liabilities of specific  inhibition modalities with respect to efficacy in vivo, and  provides valuable biochemical insights to help medicinal  chemists and pharmacologists most effectively pursue lead  optimization. It includes two new chapters, one on the  pioneering idea of drug-target residence time fostered by  Dr. Copeland, and the second on quantitative biochemistry.  Five new appendices are added"--Provided by publisher.},
      url = {http://library.usi.edu/record/487624},
}