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1. Introduction
Part I. Osteoarthritis of the knee or hip
2. Epidemiology, pathogenesis, and clinical aspects
3. Therapeutic options
Part II. Functional decline
4. Risk factors for functional decline
5. Neuromuscular mechanisms explaining functional decline
6. Behavioral mechanisms explaining functional decline
Part III. Exercise therapy
7.Regular exercise therapy
8. Exercise aiming at neuromuscular mechanisms
9. Exercise aiming at behavioral mechanisms
10. Comorbidity, overweight, and exercise
11. Concluding remarks.

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