000695531 000__ 03504cam\a2200445Ki\4500 000695531 001__ 695531 000695531 005__ 20230306135444.0 000695531 006__ m\\\\\o\\d\\\\\\\\ 000695531 007__ cr\cnu|||unuuu 000695531 008__ 131007t20132014ne\a\\\\o\\\\\001\0\eng\d 000695531 020__ $$a9789400774384 $$qelectronic book 000695531 020__ $$a9400774389 $$qelectronic book 000695531 020__ $$z9789400774377 000695531 0247_ $$a10.1007/978-94-007-7438-4$$2doi 000695531 035__ $$aSP(OCoLC)ocn859524994 000695531 035__ $$aSP(OCoLC)859524994 000695531 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDXCP$$dEBLCP$$dOCLCQ$$dN$T$$dCOO$$dOHS$$dDEBSZ 000695531 049__ $$aISEA 000695531 050_4 $$aQR201.M3 000695531 08204 $$a614.5/32$$223 000695531 24500 $$aHeat shock proteins of malaria$$h[electronic resource] /$$cAddmore Shonhai, Gregory L. Blatch, editors. 000695531 264_1 $$aDordrecht :$$bSpringer,$$c[2013?] 000695531 264_4 $$c©2014 000695531 300__ $$a1 online resource (viii, 223 pages) :$$billustrations (some color) 000695531 336__ $$atext$$btxt$$2rdacontent 000695531 337__ $$acomputer$$bc$$2rdamedia 000695531 338__ $$aonline resource$$bcr$$2rdacarrier 000695531 500__ $$aIncludes index. 000695531 5050_ $$aIntroduction: The importance of molecular chaperones in survival and pathogenesis of the malaria parasite Plasmodium falciparum -- General structural and functional features of molecular chaperones -- The role of Hsp70s in the development and pathogenicity of Plasmodium species -- Role of the Hsp40 family of proteins in the survival and pathogenesis of the malaria parasite -- Role of Hsp90 in Plasmodium falciparum malaria -- The role of parasite heat shock proteins in protein trafficking and host cell remodeling -- Role of heat shock proteins in immune modulation in malaria -- Establishment of Plasmodium falciparum extracellular compartments in its host erythrocyte -- Chaperones and Proteases of Plasmodium falciparum -- Heat shock proteins as targets for novel anti-malarial drugs -- Heat shock proteins of Malaria: What do we not know, and what should the future focus be? 000695531 506__ $$aAccess limited to authorized users. 000695531 520__ $$aThis book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored. 000695531 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed September 24, 2013). 000695531 650_0 $$aMalaria$$xMolecular aspects. 000695531 650_0 $$aHeat shock proteins. 000695531 7001_ $$aShonhai, Addmore,$$eeditor of compilation. 000695531 7001_ $$aBlatch, Gregory L.,$$eeditor of compilation. 000695531 85280 $$bebk$$hSpringerLink 000695531 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-94-007-7438-4$$zOnline Access 000695531 909CO $$ooai:library.usi.edu:695531$$pGLOBAL_SET 000695531 980__ $$aEBOOK 000695531 980__ $$aBIB 000695531 982__ $$aEbook 000695531 983__ $$aOnline 000695531 994__ $$a92$$bISE