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Stem cells and cancer stem cells. Volume 11, Therapeutic applications in disease and injury [electronic resource] / edited by M.A. Hayat.

Hayat, M. A., 1940- editor of compilation.
2013
QH588.S83
Available Online
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Title
Stem cells and cancer stem cells. Volume 11, Therapeutic applications in disease and injury [electronic resource] / edited by M.A. Hayat.
ISBN
9789400773295 electronic book
9400773293 electronic book
9789400773288
DOI
https://doi.org/10.1007/978-94-007-7329-5
Published
Dordrecht : Springer, 2013.
Language
English
Description
1 online resource.
Item Number
10.1007/978-94-007-7329-5 doi
Call Number
QH588.S83
Dewey Decimal Classification
614.5999
Summary
Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods.
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Added Author
Hayat, M. A., 1940- editor of compilation.
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Stem cells and cancer stem cells. Volume 11, Therapeutic applications in disease and injury
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Preface. I. Embryonic stem cells
Maintenance of human embryonic stem cell identity and Inhibition of extraembryonic differentiation: Role of cnot1, cnot2 and cnot3.-Investigating the role of the embryonic stem cell self-renewal gene nanog in neoplastic processes
Derivation and expansion of human embryonic stem cells under xeno-free, defined conditions
Self-renewal of nave state mouse embryonic stem cells: Role of lacdinac in lif/stat3 signaling
Cancer gene therapy potential of neural stem cells derived from human embryonic stem cells and induced pluripotent stem cells. II. Cancer stem cells
The role of cancer stem(-like) cells and epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma
Glioma propagating cells show enhanced chemoresistance and radioresistance (an update)
Chemical genomic approaches to eradicate leukemia stem cells
Isolation of cancer stem cells showing drug resistance in the human epithelia ovarian cancer
Cancer stem cells in pediatric sarcomas
Cancer stem cells derived from mouse induced pluripotent stem cells
Stemness regulation of somatic cancer cells
Induced differentiation of brain tumour stem cells
Role of microenvironment in regulating stem cell and tumor initiating cancer cell behavior and its potential therapeutic implications
Identification of ovarian cancer stem cells: molecular pathways. III. Hematopoietic stem cells
Hematopoietic stem cells and bone regeneration
Children with solid tumors: identification of ematopoietic and endothelial progenitor cells as biomarkers
Pediatric neuroblastoma: combined treatment with monoclonal antibody and cytokines preceded by matopoietic stem cell transplantation
Autologous and allogeneic hematopoieitic cell transplantation: risk of second malignancies. IV. Neural stem cells
Treatment of injured spinal cord: engraftment of neural stem cells
Spinal cord injury ngineering using neural stem cells
Endogenous regenerative potential of neural stem/progenitor cells of the newborn brain (an overview).Index.

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