TY  - GEN
N2  - G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.
AB  - G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.
T1  - G Protein-coupled receptors-- Modeling and simulation
DA  - ©2014.
CY  - Dordrecht :
AU  - Filizola, Marta.
CN  - SpringerLink
CN  - QP551
PB  - Springer,
PP  - Dordrecht :
PY  - ©2014.
N1  - Includes index.
ID  - 695806
KW  - G proteins
SN  - 9789400774230
SN  - 9400774230
TI  - G Protein-coupled receptors-- Modeling and simulation
LK  - https://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-94-007-7423-0
UR  - https://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-94-007-7423-0
ER  -