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000695806 0167_ $$a016609946$$2Uk
000695806 020__ $$a9789400774230$$qelectronic book
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000695806 050_4 $$aQP551$$b.F384 2013
000695806 08204 $$a570.285
000695806 24500 $$aG Protein-coupled receptors-- Modeling and simulation$$h[electronic resource] /$$cMarta Filizola, editors.
000695806 260__ $$aDordrecht :$$bSpringer,$$c©2014.
000695806 300__ $$a1 online resource (228 pages).
000695806 336__ $$atext$$btxt$$2rdacontent
000695806 337__ $$acomputer$$bc$$2rdamedia
000695806 338__ $$aonline resource$$bcr$$2rdacarrier
000695806 4901_ $$aAdvances in Experimental Medicine and Biology
000695806 500__ $$aIncludes index.
000695806 5050_ $$aPreface. Section I Progress in Structural Modeling of GPCRs -- The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expanding the Scope of Homology Modeling -- Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes. Section II. GPCRs in Motion: Insights from Simulations -- Structure and Dynamics of G Protein-Coupled Receptors -- How the Dynamic Properties and Functional Mechanisms of GPCRs are Modulated by their Coupling to the Membrane Environment -- Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol with Rhodopsin -- Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receptors with Enhanced Molecular Dynamics Methods. Section III. GPCR-Focused Rational Design and Mathematical Modeling -- From Three-Dimensional GPCR Structure to Rational Ligand Discovery -- Mathematical Modeling Of G Protein-Coupled Receptor Function: What Can We Learn From Empirical And Mechanistic Models? Section IV. Bioinformatics Tools and Resources for GPCRs -- GPCRs & Company: Databases and Servers for GPCRs and Interacting Partners -- Bioinformatics Tools for Predicting GPCR Gene Functions. Index.
000695806 506__ $$aAccess limited to authorized users.
000695806 520__ $$aG protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.
000695806 588__ $$aDescription based on print version record.
000695806 650_0 $$aG proteins$$xReceptors.
000695806 7001_ $$aFilizola, Marta.
000695806 77608 $$iPrint version:$$z9789400774223
000695806 830_0 $$aAdvances in experimental medicine and biology.
000695806 85280 $$bebk$$hSpringerLink
000695806 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-94-007-7423-0$$zOnline Access
000695806 909CO $$ooai:library.usi.edu:695806$$pGLOBAL_SET
000695806 980__ $$aEBOOK
000695806 980__ $$aBIB
000695806 982__ $$aEbook
000695806 983__ $$aOnline
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