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000695867 019__ $$a864358423
000695867 020__ $$a9784431544425 $$qelectronic book
000695867 020__ $$a4431544429 $$qelectronic book
000695867 020__ $$z9784431544418
000695867 020__ $$z4431544410
000695867 0247_ $$a10.1007/978-4-431-54442-5$$2doi
000695867 035__ $$aSP(OCoLC)ocn864017437
000695867 035__ $$aSP(OCoLC)864017437$$z(OCoLC)864358423
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000695867 049__ $$aISEA
000695867 050_4 $$aQR185.8.C95
000695867 08204 $$a616.07/9$$223
000695867 24500 $$aCytokine frontiers$$h[electronic resource] :$$bregulation of immune responses in health and disease /$$cTakayuki Yoshimoto, Tomohiro Yoshimoto, editors.
000695867 264_1 $$aTokyo :$$bSpringer,$$c2014.
000695867 300__ $$a1 online resource (xii, 396 pages) :$$bcolor illustrations.
000695867 336__ $$atext$$btxt$$2rdacontent
000695867 337__ $$acomputer$$bc$$2rdamedia
000695867 338__ $$aonline resource$$bcr$$2rdacarrier
000695867 500__ $$aIncludes index.
000695867 5050_ $$aPart I. Cytokines in Inflammatory Disorders -- 1 The Interleukin-1 Family2 IL-6 and Inflammatory Diseases -- 3 The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders -- 4 IL-18 -- 5 Interleukin-21: A Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential -- 6 Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells -- 7 IL-23 in Health and Disease -- 8 IL-36: An Epithelial Cytokine Important in Psoriasis -- 9 Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure -- Part II. Cytokines in Allergic Disorders -- 10 Interleukin-25: A Key Initiator of Type 2 Immune Responses -- 11 Interleukin-33: A Multifunctional Alarmin that Promotes Both Health and Disease -- 12 Thymic Stromal Lymphopoietin (TSLP) -- Part III. Cytokines in Immunological Tolerance and Anti-inflammation -- 13 Interleukin-10: Cytokines in Anti-inflammation and Tolerance -- 14 Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties -- 15 Interleukin-35: A Novel Mediator of Peripheral Tolerance.
000695867 506__ $$aAccess limited to authorized users.
000695867 520__ $$aThis book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
000695867 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed November 4, 2013).
000695867 650_0 $$aCytokines.
000695867 7001_ $$aYoshimoto, Takayuki,$$eeditor of compilation.
000695867 7001_ $$aYoshimoto, Tomohiro,$$eeditor of compilation.
000695867 77608 $$cOriginal$$z9784431544418$$z4431544410$$w(OCoLC)843859191
000695867 85280 $$bebk$$hSpringerLink
000695867 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-4-431-54442-5$$zOnline Access
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000695867 980__ $$aEBOOK
000695867 980__ $$aBIB
000695867 982__ $$aEbook
000695867 983__ $$aOnline
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