Calcium signaling in airway smooth muscle cells [electronic resource] / Yong-Xiao Wang, editor.
Wang, Yong-Xiao, editor of compilation.
2014
QP535.C2
Available Online

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Title Calcium signaling in airway smooth muscle cells [electronic resource] / Yong-Xiao Wang, editor.
ISBN 9783319013121 electronic book
3319013122 electronic book
9783319013114
DOI https://doi.org/10.1007/978-3-319-01312-1
Published Cham : Springer, 2014.
Language English
Description 1 online resource (xiv, 469 pages) : illustrations (some color)
Other Standard Identifiers 10.1007/978-3-319-01312-1 doi
Call Number QP535.C2
Dewey Decimal Classification 572/.516
Summary Calcium signaling plays an important role in cellular responses in almost all types of cells including airway smooth muscle cells. This universal signaling may result from extracellular calcium influx and/or intracellular calcium release, which are precisely controlled and regulated by ion channels, exchangers and/or transporters on the plasmalemmal or sarcoplasmic reticulum membrane. First, several chapters detail calcium release channels (ryanodine receptors and inositol trisphosphate receptors), voltage-dependent potassium channels, transient receptor potential channels, Orai channels, calcium-activated potassium channels, and calcium-activated chloride channels. Discussion of well-characterized sodium-calcium exchangers, voltage-dependent calcium channels, and calcium pumps are described in depth over many chapters. Ca2+ signaling can be expressed in Ca2+ sparks, waves, oscillations, and global changes in intracellular Ca2+ concentration. Calcium in subcellular compartments (cytosol, sarcoplasmic reticulum, mitochondria, and caveolae) also exhibit dynamic crosstalk. Many molecules including FK506 binding proteins, cyclic adenosine diphosphate ribose, reactive oxygen species, RhoA kinases, caveolin and integrins can modify and induce spatial, temporal and compartmental variations of calcium signaling. In addition, calcium signaling can exhibit sex hormone- and age-dependent changes. A number of chapters are dedicated to covering these diverse formats, spatiotemporal characteristics, multifaceted network and mathematical modeling of Ca2+ signaling. Neurotransmitters, hormones, growth factors, inflammatory cytokines, and other stimuli may lead to multiple cellular responses by inducing Ca2+ signaling in airway smooth muscle cells. Increasing evidence suggests that Ca2+ pumps and canonical transient receptor potential channels are essential for airway smooth muscle remodeling. Accordingly, several chapters summarize recent advances in the studies of the key role of calcium signaling in physiological cellular responses as well as the development of asthma, chronic obstructive pulmonary disease and other respiratory disorders.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (SpringerLink, viewed November 4, 2013).
Added Author Wang, Yong-Xiao, editor of compilation.
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Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells
Kv7 (KCNQ) Potassium Channels and L-type Calcium Channels in the Regulation of Airway Diameter
Transient Receptor Potential and Orai Channels in Airway Smooth Muscle Cells
Large-conductance calcium-activated potassium channels
Calcium-activated Chloride Channels
Local Calcium Signaling in Airway Smooth Muscle Cells
Regulation of Airway Smooth Muscle Contraction by Ca2+ Signaling: Physiology Revealed by Microscopy Studies of Lung Slices
Temporal Aspects of Ca2+ Signaling in Airway Myocytes
Mechanisms Underlying Ca2+ Store Refilling in Airway Smooth Muscle
Novel Mechanisms in Ca2+-homeostasis and Internal Store Refilling of Airway Smooth Muscle
The Role of Mitochondria in Calcium Regulation in Airway Smooth Muscle
Role of Caveolae in the Airway
CD38 : Cyclic ADP-ribose-mediated Calcium Signaling in Airway Myocytes
The Pathways and Signaling Cross-talk with Oxidant in Calcium Influx in Airway Smooth Muscle Cells
Role of RhoA/Rho-kinase and Calcium Sensitivity in Airway Smooth Muscle Functions
Role of Integrins in the Regulation of Calcium Signaling
Sex Steroid Signaling in the Airway
Regulation of Contractility in Immature Airway Smooth Muscle
Mathematical Modeling of Calcium Dynamics in Airway Smooth Muscle Cells
Effects of Inflammatory Cytokines on Ca2+ Homeostasis in Airway Smooth Muscle Cells
Ca2+ Signaling and P2 Receptors in Airway Smooth Muscle
Calcium Signaling in Airway Smooth Muscle Remodeling
Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle
Modulation of Airway Smooth Muscle Contractile Function by TNFa and IL-13 and Airway Hyper-responsiveness in Asthma
Airway Smooth Muscle Malfunction in COPD.

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