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000696130 020__ $$a9781461491675 $$qelectronic book
000696130 020__ $$a1461491673 $$qelectronic book
000696130 020__ $$z9781461491668
000696130 0247_ $$a10.1007/978-1-4614-9167-5$$2doi
000696130 035__ $$aSP(OCoLC)ocn865580717
000696130 035__ $$aSP(OCoLC)865580717
000696130 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dIDEBK$$dYDXCP$$dE7B$$dCOO$$dOHS$$dVT2
000696130 049__ $$aISEA
000696130 050_4 $$aRB150.A67
000696130 08204 $$a614.5999$$223
000696130 24500 $$aHypoxia and cancer$$h[electronic resource] :$$bbiological implications and therapeutic opportunities /$$cGiovanni Melillo, editor.
000696130 264_1 $$aNew York :$$bSpringer,$$c2014.
000696130 300__ $$a1 online resource (xiv, 363 pages) :$$billustrations (some color).
000696130 336__ $$atext$$btxt$$2rdacontent
000696130 337__ $$acomputer$$bc$$2rdamedia
000696130 338__ $$aonline resource$$bcr$$2rdacarrier
000696130 4901_ $$aCancer Drug Discovery and Development,$$x2196-9906
000696130 500__ $$aIncludes index.
000696130 5050_ $$aPreface -- Hypoxia and breast cancer metastasis -- Hypoxia and the DNA damage response -- Hypoxia and non-coding RNAs -- Hypoxia and ROS -- Hypoxia and gene expression -- Carbonic anhydrase IX: from biology to therapy -- Imaging the hypoxic tumor microenvironment in preclinical models -- Clinical imaging of hypoxia -- Hypoxia, antiangiogenic therapy and metastasis -- UPR and therapeutic opportunities -- Targeting the hypoxic phenotype -- Marianne Nordsmark: Hypoxia and Radiation therapy -- Pharmacological strategies targeting hypoxia -- Targeting the hypoxic tumor microenvironment -- Clinical exploitation of hypoxia -- Index.$$cỹ
000696130 506__ $$aAccess limited to authorized users.
000696130 520__ $$aThe tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for understanding how hypoxia impacts the biology, imaging and therapy of human cancers. Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy.
000696130 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed November 11, 2013).
000696130 650_0 $$aAnoxemia.
000696130 650_0 $$aCancer cells.
000696130 650_0 $$aCancer$$xMolecular aspects.
000696130 7001_ $$aMelillo, Giovanni,$$eeditor of compilation.
000696130 830_0 $$aCancer drug discovery and development,$$x2196-9906
000696130 85280 $$bebk$$hSpringerLink
000696130 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4614-9167-5$$zOnline Access
000696130 909CO $$ooai:library.usi.edu:696130$$pGLOBAL_SET
000696130 980__ $$aEBOOK
000696130 980__ $$aBIB
000696130 982__ $$aEbook
000696130 983__ $$aOnline
000696130 994__ $$a92$$bISE