Hypoxia and cancer [electronic resource] : biological implications and therapeutic opportunities / Giovanni Melillo, editor.
Melillo, Giovanni, editor of compilation.
2014
RB150.A67
Available Online

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Title Hypoxia and cancer [electronic resource] : biological implications and therapeutic opportunities / Giovanni Melillo, editor.
ISBN 9781461491675 electronic book
1461491673 electronic book
9781461491668
DOI https://doi.org/10.1007/978-1-4614-9167-5
Published New York : Springer, 2014.
Language English
Description 1 online resource (xiv, 363 pages) : illustrations (some color).
Item Number 10.1007/978-1-4614-9167-5 doi
Call Number RB150.A67
Dewey Decimal Classification 614.5999
Summary The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for understanding how hypoxia impacts the biology, imaging and therapy of human cancers. Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (SpringerLink, viewed November 11, 2013).
Added Author Melillo, Giovanni, editor of compilation.
Series Cancer drug discovery and development, 2196-9906
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Record Appears in Online Resources > Ebooks
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Preface
Hypoxia and breast cancer metastasis
Hypoxia and the DNA damage response
Hypoxia and non-coding RNAs
Hypoxia and ROS
Hypoxia and gene expression
Carbonic anhydrase IX: from biology to therapy
Imaging the hypoxic tumor microenvironment in preclinical models
Clinical imaging of hypoxia
Hypoxia, antiangiogenic therapy and metastasis
UPR and therapeutic opportunities
Targeting the hypoxic phenotype
Marianne Nordsmark: Hypoxia and Radiation therapy
Pharmacological strategies targeting hypoxia
Targeting the hypoxic tumor microenvironment
Clinical exploitation of hypoxia
Index.

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