Indacaterol [electronic resource] : the first once-daily long-acting Beta2 Agonist for COPD / Alexandre Trifilieff, editor.
Trifilieff, Alexandre, editor of compilation.
2014
RC776.O3
Available Online

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Title
Indacaterol [electronic resource] : the first once-daily long-acting Beta2 Agonist for COPD / Alexandre Trifilieff, editor.
ISBN
9783034807098 electronic book
3034807090 electronic book
9783034807081
DOI
https://doi.org/10.1007/978-3-0348-0709-8
Published
Basel : Springer, 2014.
Language
English
Description
1 online resource (vii, 146 pages) : illustrations (some color).
Item Number
10.1007/978-3-0348-0709-8 doi
Call Number
RC776.O3
Dewey Decimal Classification
616.2/4
Summary
Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled 2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from PDF title page (SpringerLink, viewed November 18, 2013).
Added Author
Trifilieff, Alexandre, editor of compilation.
Series
Milestones in drug therapy, 2296-6056
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Online Access
Record Appears in
Online Resources > Ebooks
All Resources
Current Pharmacotherapy for COPD
The preclinical pharmacology of indacaterol
The design of the indacaterol molecule
The early clinical development of Indacaterol
INHANCE: An adaptive confirmatory study with dose selection at interim
Phase III clinical efficacy studies: lung function
Phase III Clinical Efficacy of Indacaterol
Patient-centered Outcomes
The history and performance of the Breezhaler device
What does the future hold for the therapy of COPD?.

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