000696287 000__ 03960cam\a2200457Ki\4500 000696287 001__ 696287 000696287 005__ 20230306135647.0 000696287 006__ m\\\\\o\\d\\\\\\\\ 000696287 007__ cr\cnu|||unuuu 000696287 008__ 140110s2014\\\\sz\a\\\\omb\\\000\0\eng\d 000696287 020__ $$a9783319011899 $$qelectronic book 000696287 020__ $$a3319011898 $$qelectronic book 000696287 020__ $$z9783319011882 000696287 0247_ $$a10.1007/978-3-319-01189-9$$2doi 000696287 035__ $$aSP(OCoLC)ocn867847128 000696287 035__ $$aSP(OCoLC)867847128 000696287 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dYDXCP$$dCOO$$dIDEBK 000696287 049__ $$aISEA 000696287 050_4 $$aRM303 000696287 08204 $$a615.7$$223 000696287 1001_ $$aGonzález, Zacarías León,$$eauthor. 000696287 24510 $$aPercutaneous absorption of UV filters contained in sunscreen cosmetic products$$h[electronic resource] :$$bdevelopment of analytical methods /$$cZacarías León González. 000696287 264_1 $$aCham :$$bSpringer,$$c2014. 000696287 300__ $$a1 online resource (xviii, 216 pages) :$$billustrations (some color). 000696287 336__ $$atext$$btxt$$2rdacontent 000696287 337__ $$acomputer$$bc$$2rdamedia 000696287 338__ $$aonline resource$$bcr$$2rdacarrier 000696287 4901_ $$aSpringer Theses,$$x2190-5053 000696287 502__ $$bPh.D.$$cUniversity of Valencia$$d[2013?] 000696287 504__ $$aIncludes bibliographical references. 000696287 5050_ $$aSunscreen Cosmetics: Advantages and Drawbacks -- Development of a Chromatographic Method to Estimate the In Vitro Percutaneous Absorption of Hydrosoluble UV Filters -- Determination of the Unconjugated Forms of Benzophenone-3 and Benzophenone-4 in Urine by Solid-Phase Extraction Coupled to a Liquid Chromatographic System with UV/VIS Detection by Using Autormated Sequential Injection Analysis -- Determination of Benzophenone-3 and Their Metabolites in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry -- Determination of Benzophenone-3 and Its Metabolites in Human Semen by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectroscopy -- Eluciation of the In Vitro Biotransformation Products of Ethylhexyl Dimthyl PABA by Chromatographic Techniques Coupled to Mass Spectrometry -- Elucidation of the In Vivo Biotransformation Products of Ethylhexyl Dimethyl PABA By Liquid Chromatographic Techniques with Mass Spectrometry Detectors -- Determination of Ethylhexl Dimethyl PABA and Its Metabolites in Semen by Automated Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry -- Determination of Methyl Benzylidene Camphor and Its Main Metabolite in Urine by Solid-Phase Extraction and Liquid Chromatography Tandem Mass Spectrometry -- Summary and General Conclusions. 000696287 506__ $$aAccess limited to authorized users. 000696287 520__ $$aZacarias Leon's thesis describes the development and validation of analytical methods to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. Leon describes these methods in both in vitro and non-invasive in vivo methodologies. Currently dermatologists recommend the use of sunscreen products not only under conditions of extreme exposure to the sun but also in daily situations. However the chemical compounds in these products contain may lead to undesired processes and cause induced toxicity, estogenic effects and endocrine activity. Leon establishes methods to investigate these effects and provides valuable information on the undesired side effects associated with the use of UV filters found in sunscreen products. The work in this thesis has led to a number of publications in renowned analytical chemistry journals. 000696287 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed January 3, 2014). 000696287 650_0 $$aSkin absorption. 000696287 650_0 $$aSunscreens (Cosmetics)$$xSide effects. 000696287 830_0 $$aSpringer theses,$$x2190-5053 000696287 85280 $$bebk$$hSpringerLink 000696287 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-3-319-01189-9$$zOnline Access 000696287 909CO $$ooai:library.usi.edu:696287$$pGLOBAL_SET 000696287 980__ $$aEBOOK 000696287 980__ $$aBIB 000696287 982__ $$aEbook 000696287 983__ $$aOnline 000696287 994__ $$a92$$bISE