Mosaicism in human skin [electronic resource] : understanding nevi, nevoid skin disorders, and cutaneous neoplasia / by Rudolf Happle.

Mosaicism in human skin [electronic resource] : understanding nevi, nevoid skin disorders, and cutaneous neoplasia / by Rudolf Happle.

9783642387654 electronic book
3642387659 electronic book
9783642387647

Heidelberg : Springer, 2014.

English

1 online resource.

10.1007/978-3-642-38765-4 doi

RL71

616.5

Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders. This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devotedto the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.

Includes bibliographical references and index.

Access limited to authorized users.

Description based on print version record.

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