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000696413 020__ $$a9789400773059 $$qelectronic book
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000696413 0247_ $$a10.1007/978-94-007-7305-9$$2doi
000696413 035__ $$aSP(OCoLC)ocn868229977
000696413 035__ $$aSP(OCoLC)868229977
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000696413 050_4 $$aQL368.E95
000696413 08204 $$a616.9/6$$223
000696413 24500 $$aProteins and proteomics of Leishmania and Trypanosoma$$h[electronic resource]  /$$cAndré L.S. Santos, Marta H. Branquinha, Claudia M. d'Avila-Levy, Lucimar F. Kneipp, Cátia L. Sodré, editors.
000696413 264_1 $$aDordrecht :$$bSpringer,$$c2014.
000696413 300__ $$a1 online resource (x, 381 pages) :$$billustrations (some color).
000696413 336__ $$atext$$btxt$$2rdacontent
000696413 337__ $$acomputer$$bc$$2rdamedia
000696413 338__ $$aonline resource$$bcr$$2rdacarrier
000696413 4901_ $$aSubcellular Biochemistry,$$x0306-0225 ;$$v74
000696413 500__ $$aIncludes index.
000696413 5050_ $$aBiology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure -- Selection of Molecular Targets for Drug Development against Trypanosomatids -- A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development -- Arginase in Leishmania -- The heat shock proteins of Trypanosoma cruzi -- The Gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms -- The Gp85 Surface Glycoproteins from Trypanosoma cruzi -- Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications -- Surface Topology Evolution of Trypanosoma Trans-Sialidase -- Ecto-Nucleotidases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites -- Gp63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects -- Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis -- The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biological Applications for Drug Target Discovery -- Proteomics advances in the study of Leishmania parasites and leishmaniasis -- Towards the Phosphoproteome of Trypanosomatids.
000696413 506__ $$aAccess limited to authorized users.
000696413 520__ $$aThis book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids genera are etiological agents of leishmaniasis, Chagas' disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quite unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book "Proteins and Proteome of Leishmania and Trypanosoma" encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
000696413 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed November 25, 2013).
000696413 650_0 $$aTrypanosomatidae.
000696413 650_0 $$aTrypanosomiasis.
000696413 650_0 $$aLeishmaniasis.
000696413 650_0 $$aMedical parasitology.
000696413 7001_ $$aSantos, Andre L. S.,$$eeditor of compilation.
000696413 830_0 $$aSub-cellular biochemistry ;$$v74.$$x0306-0225
000696413 85280 $$bebk$$hSpringerLink
000696413 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-94-007-7305-9$$zOnline Access
000696413 909CO $$ooai:library.usi.edu:696413$$pGLOBAL_SET
000696413 980__ $$aEBOOK
000696413 980__ $$aBIB
000696413 982__ $$aEbook
000696413 983__ $$aOnline
000696413 994__ $$a92$$bISE