000696440 000__ 03461cam\a2200469Ki\4500 000696440 001__ 696440 000696440 005__ 20230306135557.0 000696440 006__ m\\\\\o\\d\\\\\\\\ 000696440 007__ cr\cnu|||unuuu 000696440 008__ 140120s2014\\\\sz\a\\\\o\\\\\000\0\eng\d 000696440 020__ $$a9783034807067 $$qelectronic book 000696440 020__ $$a3034807066 $$qelectronic book 000696440 020__ $$z9783034807050 000696440 0247_ $$a10.1007/978-3-0348-0706-7$$2doi 000696440 035__ $$aSP(OCoLC)ocn868588313 000696440 035__ $$aSP(OCoLC)868588313 000696440 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dYDXCP$$dCOO 000696440 049__ $$aISEA 000696440 050_4 $$aRC600 000696440 08204 $$a616.97/806$$223 000696440 24500 $$aDrugs targeting B-cells in autoimmune diseases$$h[electronic resource] /$$cXavier Bosch, Manuel Ramos-Casals, Munther A. Khamashta, editors. 000696440 264_1 $$aBasel :$$bSpringer,$$c2014. 000696440 300__ $$a1 online resource (xi, 292 pages) :$$billustrations (some color). 000696440 336__ $$atext$$btxt$$2rdacontent 000696440 337__ $$acomputer$$bc$$2rdamedia 000696440 338__ $$aonline resource$$bcr$$2rdacarrier 000696440 4901_ $$aMilestones in Drug Therapy,$$x2296-6056 000696440 500__ $$aIncludes index. 000696440 5050_ $$aHistoric outline of the development of drugs targeting B-cells -- Understanding B-cell biology -- Pharmacological effects and mechanisms of action of agents blocking B cells -- Systemic lupus erythematosus: direct B-cell blocking -- Systemic lupus erythematosus: indirect B-cell blocking -- B-cell targeted therapies in rheumatoid arthritis -- B-cell targeted therapies in Primary Sj?gren Syndrome -- Targeting B cells in ANCA-associated vasculitis -- B-cell targeted therapies in systemic sclerosis and inflammatory myopathies -- B-cell targeted therapies in cryoglobulinemia -- B-cell targeted therapies in autoimmune cytopenias and thrombosis -- Targeting B cells in neurological autoimmune diseases -- Targeting B cells in other systemic autoimmune diseases -- Safety of B-cell targeted therapies -- The future potential of biosimilars targeting B-cells. 000696440 506__ $$aAccess limited to authorized users. 000696440 520__ $$aThis book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjogren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases. 000696440 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed November 25, 2013). 000696440 650_0 $$aAutoimmune diseases$$xChemotherapy. 000696440 650_0 $$aB cells. 000696440 7001_ $$aBosch, Xavier,$$eeditor of compilation. 000696440 7001_ $$aRamos-Casals, Manuel,$$eeditor of compilation. 000696440 7001_ $$aKhamashta, Munther A.,$$eeditor of compilation. 000696440 830_0 $$aMilestones in drug therapy,$$x2296-6056 000696440 85280 $$bebk$$hSpringerLink 000696440 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-3-0348-0706-7$$zOnline Access 000696440 909CO $$ooai:library.usi.edu:696440$$pGLOBAL_SET 000696440 980__ $$aEBOOK 000696440 980__ $$aBIB 000696440 982__ $$aEbook 000696440 983__ $$aOnline 000696440 994__ $$a92$$bISE