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000696449 0167_ $$a016499483$$2Uk
000696449 020__ $$a9781461490999 $$qelectronic book
000696449 020__ $$a1461490995 $$qelectronic book
000696449 020__ $$z9781461490982
000696449 0247_ $$a10.1007/978-1-4614-9099-9$$2doi
000696449 035__ $$aSP(OCoLC)ocn868679791
000696449 035__ $$aSP(OCoLC)868679791
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000696449 050_4 $$aQP609.P78
000696449 08204 $$a572/.76$$223
000696449 24500 $$aRole of proteases in cellular dysfunction$$h[electronic resource]  /$$cNaranjan S. Dhalla, Sajal Chakraborti, editors.
000696449 264_1 $$aNew York, NY :$$bSpringer,$$c2014.
000696449 300__ $$a1 online resource (xi, 462 pages) :$$billustrations (some color).
000696449 336__ $$atext$$btxt$$2rdacontent
000696449 337__ $$acomputer$$bc$$2rdamedia
000696449 338__ $$aonline resource$$bcr$$2rdacarrier
000696449 4901_ $$aAdvances in Biochemistry in Health and Disease ;$$vvolume 8
000696449 500__ $$aIncludes index.
000696449 5050_ $$aPart A: Proteases and Neural Disorders.-Role of Calpain in Immunobiology of Neurodegenerative Diseases.-Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration.-Involvement of Caspases in Neurodegenaration and Stroke.-Matrix Metalloproteinases in Ischemia-Reperfusion Injury in Brain: Antioxidants as Rescuer.-The Role of Matrix Metalloproteinases in Neurovascular Injury.-The Role of Proteases in Embryonic Neural Crest Cells.-Part B: Proteases and Cancer -- Proteases and Cancer Development.-Matrix Metalloproteinase and its Inhibitors in Cancer Progression.-Ubiquitin-Proteosome System in the Hallmarks of Cancer.-Matrix Metalloproteinases in Cancer Metastasis: An unsolved Mystery.-A Disintegrin and Metalloprotease-12 as a New target for Cancer Treatment -- Proteases and Their Role in Drug Development with an Emphasis in Cancer.-Part C: Proteases and Cardiovascular Defects.-Role of Matrix Metalloproteinases in Atherosclerosis.-The Importance of the Urokinase-type Plasminogen Activator (uPA) and its receptor (uPAR) for the Development and Progression of Atherosclerosis.-Matrix Metalloproteinases and Hypertension.-Regulation of Proteolysis in Vascular Remodeling.-Emerging Role of Genetic Variants of Matrix Metalloproteinases Genes in Left Ventricular Dysfunction.-Implications of Intracellular Proteolytic Activation of MMP-2 in the Heart.-Matrix Metalloprotease-2 in the Development and Progression of Cardiovascular Diseases.-Role of Protease Activation in Subcellular Remodeling and Heart Failure.-Proteases as Potential Targets in Left Ventricular Remodeling After Myocardial Infarction.-MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets.-Proteases as Clinical Markers of Adverse Remodeling for Heart Failure in the Aging Population.$$cỹ
000696449 506__ $$aAccess limited to authorized users.
000696449 520__ $$aIt is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer's disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteosomal system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
000696449 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed November 25, 2013).
000696449 650_0 $$aProteolytic enzymes.
000696449 7001_ $$aDhalla, Naranjan S.,$$eeditor of compilation.
000696449 7001_ $$aChakraborti, Sajal,$$eeditor of compilation.
000696449 830_0 $$aAdvances in biochemistry in health and disease ;$$vv.8.
000696449 85280 $$bebk$$hSpringerLink
000696449 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4614-9099-9$$zOnline Access
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000696449 980__ $$aEBOOK
000696449 980__ $$aBIB
000696449 982__ $$aEbook
000696449 983__ $$aOnline
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