Design, analysis, and interpretation of genome-wide association scans [electronic resource] / Daniel O. Stram.
Stram, Daniel O., author.
2014
QH431
Available Online

Linked e-resources

Linked Resource Online Access

Details

Title Design, analysis, and interpretation of genome-wide association scans [electronic resource] / Daniel O. Stram.
Author Stram, Daniel O., author.
ISBN 9781461494430 electronic book
1461494435 electronic book
9781461494423
DOI https://doi.org/10.1007/978-1-4614-9443-0
Published New York, NY : Springer, 2014.
Language English
Description 1 online resource (xv, 334 pages) : illustrations.
Other Standard Identifiers 10.1007/978-1-4614-9443-0 doi
Call Number QH431
Dewey Decimal Classification 576.50727
Summary This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (SpringerLink, viewed November 25, 2013).
Series Statistics for biology and health, 1431-8776
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Introduction to Genome-Wide Association Studies
Topics of Quantitative Genetics
An Introduction to Association Studies
Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation
Haplotype Imputation for Association Analysis
SNP Imputation for Association Studies
Design of Large-scale Genetic Association Studies, Sample Size and Power
Post-GWAS Analyses.

Browse Subjects

Show more subjects...

Statistics

from
to
Export