Obesity and breast cancer [electronic resource] : the role of dysregulated estrogen metabolism / Kristy A. Brown, Evan R. Simpson.
2014
RC628 .B76 2014eb
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Title
Obesity and breast cancer [electronic resource] : the role of dysregulated estrogen metabolism / Kristy A. Brown, Evan R. Simpson.
Author
Brown, Kristy A., author.
ISBN
9781489980021 electronic book
1489980024 electronic book
9781489980014
1489980024 electronic book
9781489980014
Published
New York : Springer, [2014]
Copyright
©2014
Language
English
Description
1 online resource (ix, 56 pages) : illustrations (some color).
Call Number
RC628 .B76 2014eb
Dewey Decimal Classification
616.99/449071
Summary
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast.This SpringerBrief will explore all of these issues in depth and the authorsare in a unique position to write about this topic,havingextensive experience in the field of aromatase research.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from PDF title page (ebrary, viewed December 21, 2013).
Added Author
Simpson, E. R. (Evan R.), author.
Series
SpringerBriefs in cancer research.
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Table of Contents
Estrogens, adiposity and the menopause
The link between obesity and breast cancer: Epidemiological evidence
Adipose-derived and obesity-related factors and breast cancer
Estrogen biosynthesis
Therapies aimed at breaking the linkage between obesity and breast cancer
Conclusions.
The link between obesity and breast cancer: Epidemiological evidence
Adipose-derived and obesity-related factors and breast cancer
Estrogen biosynthesis
Therapies aimed at breaking the linkage between obesity and breast cancer
Conclusions.