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000696496 020__ $$a9781489980021 $$qelectronic book
000696496 020__ $$a1489980024 $$qelectronic book
000696496 020__ $$z9781489980014
000696496 035__ $$aSP(OCoLC)ocn868918491
000696496 035__ $$aSP(OCoLC)868918491
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000696496 05014 $$aRC628$$b.B76 2014eb
000696496 08204 $$a616.99/449071$$223
000696496 1001_ $$aBrown, Kristy A.,$$eauthor.
000696496 24510 $$aObesity and breast cancer$$h[electronic resource] :$$bthe role of dysregulated estrogen metabolism /$$cKristy A. Brown, Evan R. Simpson.
000696496 264_1 $$aNew York :$$bSpringer,$$c[2014]
000696496 264_4 $$c©2014
000696496 300__ $$a1 online resource (ix, 56 pages) :$$billustrations (some color).
000696496 336__ $$atext$$2rdacontent
000696496 337__ $$acomputer$$2rdamedia
000696496 338__ $$aonline resource$$2rdacarrier
000696496 4901_ $$aSpringerBriefs in cancer research
000696496 504__ $$aIncludes bibliographical references.
000696496 5050_ $$aEstrogens, adiposity and the menopause -- The link between obesity and breast cancer: Epidemiological evidence -- Adipose-derived and obesity-related factors and breast cancer -- Estrogen biosynthesis -- Therapies aimed at breaking the linkage between obesity and breast cancer -- Conclusions.
000696496 506__ $$aAccess limited to authorized users.
000696496 520__ $$aObesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast.This SpringerBrief will explore all of these issues in depth and the authorsare in a unique position to write about this topic,havingextensive experience in the field of aromatase research.
000696496 588__ $$aDescription based on online resource; title from PDF title page (ebrary, viewed December 21, 2013).
000696496 650_0 $$aEnzymes.
000696496 650_0 $$aBreast$$xCancer$$xEtiology.
000696496 650_0 $$aBreast$$xCancer$$xRisk factors.
000696496 650_0 $$aMetabolism$$xDisorders.
000696496 650_0 $$aObesity.
000696496 650_0 $$aOncology.
000696496 7001_ $$aSimpson, E. R.$$q(Evan R.),$$eauthor.
000696496 830_0 $$aSpringerBriefs in cancer research.
000696496 85280 $$bebk$$hSpringerLink
000696496 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4899-8002-1$$zOnline Access
000696496 909CO $$ooai:library.usi.edu:696496$$pGLOBAL_SET
000696496 980__ $$aEBOOK
000696496 980__ $$aBIB
000696496 982__ $$aEbook
000696496 983__ $$aOnline
000696496 994__ $$a92$$bISE