Drug delivery to the brain [electronic resource] : physiological concepts, methodologies and approaches / Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne, editors.
Hammarlund-Udenaes, Margareta.; De Lange, Elizabeth C. M.; Thorne, Robert G.
2013
RS199.5 .D78 2013eb
Available Online

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Title Drug delivery to the brain [electronic resource] : physiological concepts, methodologies and approaches / Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne, editors.
ISBN 9781461491057 electronic book
1461491053 electronic book
9781461491040
Published New York : Springer Science+Business Media, 2013.
Language English
Description 1 online resource (737 pages) : illustrations.
Call Number RS199.5 .D78 2013eb
Dewey Decimal Classification 616.807
Summary The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood -brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (viewed January 2, 2014).
Added Author Hammarlund-Udenaes, Margareta.
De Lange, Elizabeth C. M.
Thorne, Robert G.
Series AAPS advances in the pharmaceutical sciences series ; v. 10.
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Record Appears in Online Resources > Ebooks
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Part I. Physiology and basic principles for drug handling by the brain
Part II. Pharmacokinetic concepts in brain drug delivery
Part III. Industrial approaches for investigation of potential central nervous system drugs
Part IV. Strategies for improved central nervous system drug delivery
Part V. Brain drug delivery in disease conditions.

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