Title
Progress in heritable soft connective tissue diseases [electronic resource] / Jaroslava Halper, editor.
ISBN
9789400778931 electronic book
9400778937 electronic book
9789400778924
Published
Dordrecht : Springer, 2014.
Language
English
Description
1 online resource (viii, 245 pages) : illustrations (some color).
Item Number
10.1007/978-94-007-7893-1 doi
Call Number
RC924
Dewey Decimal Classification
616.7/7042
Summary
This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from PDF title page (SpringerLink, viewed January 20, 2014).
Series
Advances in experimental medicine and biology ; 802. 0065-2598
Structure, physiology and biochemistry of collagens
Basic components of connective tissues and extracellular matrix
Proteoglycans and diseases of soft tissues
Advances in the use of growth factors for treatment of disorders of soft tissues
Clinical, diagnostic, and therapeutic aspects of the Marfan syndrome
Loeys-Dietz syndrome
Connective Tissue Disorders and Cardiovascular Complications: The indomitable role of Transforming Growth Factor-beta signaling
The Ehlers-Danlos Syndrome
Ehlers?Danlos syndrome associated with glycosaminoglycan abnormalities
Cutis laxa
Collagen type VI myopathies
Mouse Models in Tendon and Ligament Research
Connective tissue disorders in domestic animals.
