000696987 000__ 03899cam\a2200457Ki\4500
000696987 001__ 696987
000696987 005__ 20230306135631.0
000696987 006__ m\\\\\o\\d\\\\\\\\
000696987 007__ cr\cn\nnnunnun
000696987 008__ 140221s2014\\\\nyua\\\\ob\\\\001\0\eng\d
000696987 020__ $$a9781489980564$$qelectronic book
000696987 020__ $$a1489980563$$qelectronic book
000696987 020__ $$z9781489980557
000696987 0247_ $$a10.1007/978-1-4899-8056-4$$2doi
000696987 035__ $$aSP(OCoLC)ocn870899231
000696987 035__ $$aSP(OCoLC)870899231
000696987 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dYDXCP$$dCOO$$dIDEBK
000696987 049__ $$aISEA
000696987 050_4 $$aQR188.6
000696987 08204 $$a616.994079$$222
000696987 24500 $$aTumor-induced immune suppression$$h[electronic resource] :$$bmechanisms and therapeutic reversal /$$cDmitry I. Gabrilovich, Arthur A. Hurwitz, editors.
000696987 250__ $$aSecond edition.
000696987 264_1 $$aNew York, NY :$$bSpringer,$$c[2014]
000696987 264_4 $$c©2014
000696987 300__ $$a1 online resource (ix, 301 pages) :$$billustrations.
000696987 336__ $$atext$$btxt$$2rdacontent
000696987 337__ $$acomputer$$bc$$2rdamedia
000696987 338__ $$aonline resource$$bcr$$2rdacarrier
000696987 504__ $$aIncludes bibliographical references and index.
000696987 5050_ $$aRegulatory T Cells and Cancer -- Th17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.-Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.-The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer.
000696987 506__ $$aAccess limited to authorized users.
000696987 520__ $$aTumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
000696987 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed Feb. 21, 2014).
000696987 650_0 $$aTumors$$xImmunological aspects.
000696987 650_0 $$aImmunosuppression.
000696987 7001_ $$aGabrilovich, Dmitry I.,$$eeditor of compilation.
000696987 7001_ $$aHurwitz, Arthur A.,$$eeditor of compilation.
000696987 85280 $$bebk$$hSpringerLink
000696987 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4899-8056-4$$zOnline Access
000696987 909CO $$ooai:library.usi.edu:696987$$pGLOBAL_SET
000696987 980__ $$aEBOOK
000696987 980__ $$aBIB
000696987 982__ $$aEbook
000696987 983__ $$aOnline
000696987 994__ $$a92$$bISE