000697021 000__ 04498cam\a2200457Ki\4500 000697021 001__ 697021 000697021 005__ 20230306135633.0 000697021 006__ m\\\\\o\\d\\\\\\\\ 000697021 007__ cr\cnu|||unuuu 000697021 008__ 140228s2014\\\\ja\a\\\\o\\\\\000\0\eng\d 000697021 0167_ $$a016636290$$2Uk 000697021 019__ $$a871207235 000697021 020__ $$a9784431547648 $$qelectronic book 000697021 020__ $$a4431547649 $$qelectronic book 000697021 020__ $$z9784431547631 000697021 0247_ $$a10.1007/978-4-431-54764-8$$2doi 000697021 035__ $$aSP(OCoLC)ocn871203177 000697021 035__ $$aSP(OCoLC)871203177$$z(OCoLC)871207235 000697021 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dUKMGB$$dYDXCP$$dCOO$$dIDEBK 000697021 049__ $$aISEA 000697021 050_4 $$aRC366 000697021 08204 $$a612.8$$223 000697021 24500 $$aSchwann cell development and pathology$$h[electronic resource] /$$cKazunori Sango, Junji Yamauchi, editors. 000697021 264_1 $$aTokyo :$$bSpringer,$$c2014. 000697021 300__ $$a1 online resource (x, 174 pages) :$$billustrations (some color) 000697021 336__ $$atext$$btxt$$2rdacontent 000697021 337__ $$acomputer$$bc$$2rdamedia 000697021 338__ $$aonline resource$$bcr$$2rdacarrier 000697021 504__ $$aIncludes bibliographical references and index. 000697021 5050_ $$a1 Introduction (Kazunori Sango and Junji Yamauchi) -- 2 Recent insights into molecular mechanisms that control growth factor receptor-mediated Schwann cell morphological changes during development (Yuki Miyamoto and Junji Yamauchi) -- 3 Membrane Skeleton in Schmidt-Lanterman Incisure in Schwann cells of Peripheral Nervous System (Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno, and Shinichi Ohno) -- 4 Schwann cell-axon interactions: the molecular and metabolic link between Schwann cells and axons (Nobuhiko Ohno, Takashi Sakoh, Yurika Saitoh, Nobuo Terada, and Shinichi Ohno) -- 5 Schwann cell-dependent regulation of peripheral nerve injury and repair (Keiichiro Susuki ) -- 6 Charcot-Marie-Tooth disease (Toru Ogata) -- 7 Expression of the transthyretin gene in Schwann cells, and familial amyloidotic polyneuropathy-mediated neurodegeneration (Tatsufumi Murakami and Yoshihide Sunada) -- 8 Node of Ranvier disruption: a key pathophysiology in immune-mediated neuropathies (Keiichiro Susuki ) -- 9 Pathogenesis of diabetic neuropathy from the viewpoint of Schwann cell abnormalities (Koichi Kato, Eva L. Feldman, and Jiro Nakamura) -- 10 Spontaneously immortalized adult rodent Schwann cells as valuable tools for the study of peripheral nerve degeneration and regeneration (Kazunori Sango, Masami Tsukamoto, Kazunori Utsunomiya, and Kazuhiko Watabe) -- BM Index. 000697021 506__ $$aAccess limited to authorized users. 000697021 520__ $$aThis book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot?Marie?Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy, and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies, have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop, a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students, and young clinicians. 000697021 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed February 17, 2014). 000697021 650_0 $$aMyelination. 000697021 650_0 $$aMyelin sheath$$xDiseases. 000697021 7001_ $$aSango, Kazunori,$$eeditor of compilation. 000697021 7001_ $$aYamauchi, Junji,$$d1953-,$$eeditor of compilation. 000697021 85280 $$bebk$$hSpringerLink 000697021 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-4-431-54764-8$$zOnline Access 000697021 909CO $$ooai:library.usi.edu:697021$$pGLOBAL_SET 000697021 980__ $$aEBOOK 000697021 980__ $$aBIB 000697021 982__ $$aEbook 000697021 983__ $$aOnline 000697021 994__ $$a92$$bISE