Epigenetic therapy of cancer [electronic resource] : preclinical models and treatment approaches / Michael Lübbert, Peter A. Jones, editors.
Lübbert, Michael, editor of compilation.; Jones, P. A. (Peter A.), editor of compilation.
2014
RC270.8
Available Online

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Title Epigenetic therapy of cancer [electronic resource] : preclinical models and treatment approaches / Michael Lübbert, Peter A. Jones, editors.
ISBN 9783642384042 electronic book
3642384048 electronic book
9783642384035
DOI https://doi.org/10.1007/978-3-642-38404-2
Published Heidelberg : Springer, 2014.
Language English
Description 1 online resource (x, 325 pages) : illustrations.
Item Number 10.1007/978-3-642-38404-2 doi
Call Number RC270.8
Dewey Decimal Classification 616.99/406
Summary The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders such as myeloid leukemias and preleukemias (myelodysplasias) is now being translated into treatment approaches that target the epigenetic defects pharmacologically. Such approaches include reactivation of tumor suppressor genes and other antiproliferative genes by reversal of DNA hypermethylation through azanucleosides, and use of HDAC inhibitors to reverse gene silencing mediated by chimeric, leukemia-specific transcription factors. This book first presents the latest evidence derived from preclinical models regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Lübbert, Michael, editor of compilation.
Jones, P. A. (Peter A.), editor of compilation.
Available in Other Form Epigenetic Therapy of Cancer
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