000697271 000__ 02679cam\a2200421Ki\4500 000697271 001__ 697271 000697271 005__ 20230306135730.0 000697271 006__ m\\\\\o\\d\\\\\\\\ 000697271 007__ cr\cnu---unuuu 000697271 008__ 140226s2014\\\\ne\a\\\\ob\\\\001\0\eng\d 000697271 020__ $$a9789401780353 $$qelectronic book 000697271 020__ $$a9401780358 $$qelectronic book 000697271 020__ $$z9789401780346 000697271 035__ $$aSP(OCoLC)ocn871044368 000697271 035__ $$aSP(OCoLC)871044368 000697271 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dYDXCP$$dEBLCP$$dE7B$$dMHW$$dIDEBK$$dCDX$$dGW5XE$$dOCLCQ$$dCOO 000697271 049__ $$aISEA 000697271 050_4 $$aRC271.N46$$bR53 2014 000697271 08204 $$a616.994061$$223 000697271 1001_ $$aRibatti, Domenico,$$d1956-$$eauthor. 000697271 24510 $$aAngiogenesis and anti-angiogenesis in hematological malignancies.$$h[electronic resource] /$$cDomenico Ribatti. 000697271 264_1 $$aDordrecht :$$bSpringer,$$c[2014] 000697271 264_4 $$c©2014 000697271 300__ $$a1 online resource :$$billustrations 000697271 336__ $$atext$$btxt$$2rdacontent 000697271 337__ $$acomputer$$bc$$2rdamedia 000697271 338__ $$aonline resource$$bcr$$2rdacarrier 000697271 504__ $$aIncludes bibliographical references and index. 000697271 5050_ $$aIntroduction -- Angiogenesis in Multiple Myeloma -- Angiogenesis in Lymphomas -- Angiogenesis in Leukemia -- Anti-angiogenesis -- Concluding Remarks. 000697271 506__ $$aAccess limited to authorized users. 000697271 520__ $$aIt has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called "vascular niche", indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies. 000697271 650_0 $$aLeukemia. 000697271 650_0 $$aNeovascularization. 000697271 650_0 $$aNeovascularization inhibitors$$xTherapeutic use. 000697271 85280 $$bebk$$hSpringerLink 000697271 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-94-017-8035-3$$zOnline Access 000697271 909CO $$ooai:library.usi.edu:697271$$pGLOBAL_SET 000697271 980__ $$aEBOOK 000697271 980__ $$aBIB 000697271 982__ $$aEbook 000697271 983__ $$aOnline 000697271 994__ $$a92$$bISE