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000697429 020__ $$a9781493904648 $$qelectronic book
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000697429 020__ $$z9781493904631
000697429 0247_ $$a10.1007/978-1-4939-0464-8$$2doi
000697429 035__ $$aSP(OCoLC)ocn875157806
000697429 035__ $$aSP(OCoLC)875157806
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000697429 050_4 $$aQP609.P55
000697429 08204 $$a572/.793$$223
000697429 24500 $$aPhospholipases in health and disease$$h[electronic resource]  /$$cParamjit S. Tappia, Naranjan S. Dhalla, editors.
000697429 264_1 $$aNew York, NY :$$bSpringer,$$c2014.
000697429 300__ $$a1 online resource (xix, 410 pages) :$$billustrations (some color).
000697429 336__ $$atext$$btxt$$2rdacontent
000697429 337__ $$acomputer$$bc$$2rdamedia
000697429 338__ $$aonline resource$$bcr$$2rdacarrier
000697429 4901_ $$aAdvances in Biochemistry in Health and Disease ;$$vvolume 10
000697429 500__ $$aIncludes index.
000697429 5050_ $$aPhospholipases in Health and Disease -- Role of Phospholipases in Regulation of Cardiolipin Biosynthesis and Remodelling in the Heart and Mammalian Cells -- Role of Phospholipases and Oxidized Phospholipids in Inflammation -- Phospholipases in Cardiovascular Disease -- The Structures and Functions of Intracellular Phospholipase A1 Family Proteins -- Phospholipase A and Breast Cancer -- Pathophysiological Aspects of Lipoprotein Associated Phospholipase A2: A Brief Overview -- Phospholipase A2 Activity Exhibited by a Bacterial Virulence Protein that Enters and Operates within a Variety of Host Cells -- Expression and Role of Phospholipase A2 in Central Nervous System Injury and Disease -- Cytoplasmic Phospholipase A2 and Autotaxin Inhibitors as Potential Radiosensitizers -- Phospholipase A2 Enzymes: Potential Targets for Therapy -- The Role of Phospholipase C Isozymes in Cellular Homeostasis -- Phospholipase C in the Immune Cell -- Phosphoinositide-specific Phospholipase C Enzymes and Cognitive Development ?and Decline -- Where life begins: Sperm PLCz in mammalian egg activation and implications in male infertility -- Oocyte Activation and Phospholipase C zeta (PLC?): Male Infertility and ?Implications for Therapeutic Intervention -- Phospholipase C Signaling in Heart Disease -- Activation of Phospholipase C in Cardiac Hypertrophy -- The Protective Effect of Phospholipase C From Cardiac Ischemia-Reperfusion Injury -- Role of Phospholipase C in Cardioprotection During Oxidative Stress -- Mammalian Phospholipase D: Structure, Regulation and Physiological Functions of Phospholipase D and its Link to Pathology -- Emerging Roles of Phospholipase D in Pathophysiological Signaling -- Alterations in Phospholipase D During the Development of Myocardial Disease.
000697429 506__ $$aAccess limited to authorized users.
000697429 520__ $$aPhospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
000697429 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, viewed March 17, 2014).
000697429 650_0 $$aPhospholipases.
000697429 7001_ $$aTappia, Paramjit S.,$$eeditor of compilation.
000697429 7001_ $$aDhalla, Naranjan S.,$$eeditor of compilation.
000697429 830_0 $$aAdvances in biochemistry in health and disease ;$$vv. 10.
000697429 85280 $$bebk$$hSpringerLink
000697429 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4939-0464-8$$zOnline Access
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000697429 980__ $$aEBOOK
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000697429 982__ $$aEbook
000697429 983__ $$aOnline
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