MicroRNA targeted cancer therapy [electronic resource] / Fazlul H. Sarkar, editor.
2014
RC271.G45
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Title
MicroRNA targeted cancer therapy [electronic resource] / Fazlul H. Sarkar, editor.
ISBN
9783319051345 electronic book
3319051342 electronic book
9783319051338
3319051342 electronic book
9783319051338
Published
Cham : Springer, 2014.
Language
English
Description
1 online resource (x, 351 pages) : illustrations (some color)
Item Number
10.1007/978-3-319-05134-5 doi
Call Number
RC271.G45
Dewey Decimal Classification
616.99/40695
Summary
Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from PDF title page (SpringerLink, May 2, 2014).
Added Author
Sarkar, Fazlul H., 1952-, editor.
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