000698034 000__ 02932cam\a2200421Ii\4500 000698034 001__ 698034 000698034 005__ 20230306135809.0 000698034 006__ m\\\\\o\\d\\\\\\\\ 000698034 007__ cr\cnu---unuuu 000698034 008__ 140502s2014\\\\sz\a\\\\o\\\\\001\0\eng\d 000698034 0167_ $$a016724572$$2Uk 000698034 020__ $$a9783319051345 $$qelectronic book 000698034 020__ $$a3319051342 $$qelectronic book 000698034 020__ $$z9783319051338 000698034 0247_ $$a10.1007/978-3-319-05134-5$$2doi 000698034 035__ $$aSP(OCoLC)ocn878949001 000698034 035__ $$aSP(OCoLC)878949001 000698034 040__ $$aGW5XE$$beng$$erda$$epn$$cGW5XE$$dN$T$$dYDXCP$$dUKMGB$$dCOO 000698034 049__ $$aISEA 000698034 050_4 $$aRC271.G45 000698034 08204 $$a616.99/40695$$223 000698034 24500 $$aMicroRNA targeted cancer therapy$$h[electronic resource] /$$cFazlul H. Sarkar, editor. 000698034 264_1 $$aCham :$$bSpringer,$$c2014. 000698034 300__ $$a1 online resource (x, 351 pages) :$$billustrations (some color) 000698034 336__ $$atext$$btxt$$2rdacontent 000698034 337__ $$acomputer$$bc$$2rdamedia 000698034 338__ $$aonline resource$$bcr$$2rdacarrier 000698034 500__ $$aIncludes index. 000698034 506__ $$aAccess limited to authorized users. 000698034 520__ $$aSince the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research. 000698034 588__ $$aDescription based on online resource; title from PDF title page (SpringerLink, May 2, 2014). 000698034 650_0 $$aCancer$$xGene therapy. 000698034 650_0 $$aCancer$$xTreatment. 000698034 7001_ $$aSarkar, Fazlul H.,$$d1952-,$$eeditor. 000698034 852__ $$bebk 000698034 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-3-319-05134-5$$zOnline Access 000698034 909CO $$ooai:library.usi.edu:698034$$pGLOBAL_SET 000698034 980__ $$aEBOOK 000698034 980__ $$aBIB 000698034 982__ $$aEbook 000698034 983__ $$aOnline 000698034 994__ $$a92$$bISE