Filaggrin [electronic resource] : basic science, epidemiology, clinical aspects and management / edited by Jacob P. Thyssen, Howard Maibach.
2014
RL793
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Title
Filaggrin [electronic resource] : basic science, epidemiology, clinical aspects and management / edited by Jacob P. Thyssen, Howard Maibach.
ISBN
9783642543791 electronic book
3642543790 electronic book
3642543782
9783642543784
3642543790 electronic book
3642543782
9783642543784
Published
Heidelberg : Springer, [2014]
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-642-54379-1 doi
Call Number
RL793
Dewey Decimal Classification
616.5/042
Summary
Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
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Filaggrin. Thyssen, epidemiology, clinical aspects and management
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