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000712028 020__ $$a9781493920075$$qelectronic book
000712028 020__ $$a1493920073$$qelectronic book
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000712028 035__ $$aSP(OCoLC)ocn894508836
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000712028 08204 $$a573.7/5$$223
000712028 1001_ $$aRall, Jack A.,$$eauthor.
000712028 24510 $$aMechanism of muscular contraction$$h[electronic resource] /$$cJack A. Rall.
000712028 264_1 $$aNew York, NY :$$bSpringer,$$c2014.
000712028 300__ $$a1 online resource (xiii, 471 pages) :$$billustrations (some color).
000712028 336__ $$atext$$btxt$$2rdacontent
000712028 337__ $$acomputer$$bc$$2rdamedia
000712028 338__ $$aonline resource$$bcr$$2rdacarrier
000712028 4901_ $$aPerspectives in Physiology
000712028 504__ $$aIncludes bibliographical references and index.
000712028 5050_ $$aSetting the Stage: Myosin, Actin, Actomyosin and ATP -- Birth of the Sliding Filament Model of Muscular Contraction: Proposal -- Glory Days: Establishment of the Sliding Filament Model of Muscular Contraction in the 1950s and 1960s -- Excitation-Contraction Coupling and the Role of Calcium in Contraction and Relaxation in the 1950s and 1960s -- Mechanics and Energetics of Muscular Contraction: Before Sliding Filaments and into the Modern Era -- 1972 Cold Spring Harbor Symposia On Quantitative Biology: The Mechanism of Muscle Contraction. Problem Solved?? -- Endosarcomeric and Exosarcomeric Cytoskeleton: Emergence of Cell and Molecular Biology in the Muscle Field -- Excitation-contraction Coupling and Regulation of Contraction in Skeletal Muscle: The Modern Synthesis -- Molecular Mechanism of Force Production: From the Difficult 1980s to the Supercharged 1990s and Beyond -- Index.
000712028 506__ $$aAccess limited to authorized users.
000712028 520__ $$aFundamental discoveries in the 1950s relating to the mechanism of muscle contraction fueled an explosion of knowledge in the latter half of the 20th century. This book traces in depth the evolution of ideas from the 1950s into the 21st century. In a scholarly yet highly readable monograph, the book describes the history on which our current understanding of muscle function is based. This is the most comprehensive study and first book-length treatment of the muscle field in over forty years. In order to provide perspective into the thinking about an issue at the time of its discovery, often the investigators describe in their own words an important result or conclusion as it appeared in an original paper. Numerous figures from the original papers are included in order to allow the reader to see the data that led to important conclusions. More than a history of experimental facts, the book describes backgrounds of many of the key investigators to allow a deeper insight into their motivations and approach to science. Controversies in the muscle field are discussed along with some missed opportunities and false trails. An amazing variety of experimental techniques have been brought to bear on the investigation of the mechanism of muscular contraction. Background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. The book is organized into nine chapters with over 170 illustrations and 1,200 references. The book provides insight into scientific thought and forms a framework for future enquiry into muscle function. The author, an emeritus professor in the department of physiology and cell biology at Ohio State University, has been a contributor to research in the muscle field for over forty years.
000712028 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 11, 2014).
000712028 650_0 $$aMuscle contraction.
000712028 830_0 $$aPerspectives in physiology.
000712028 85280 $$bebk$$hSpringerLink
000712028 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4939-2007-5$$zOnline Access
000712028 909CO $$ooai:library.usi.edu:712028$$pGLOBAL_SET
000712028 980__ $$aEBOOK
000712028 980__ $$aBIB
000712028 982__ $$aEbook
000712028 983__ $$aOnline
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