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000717120 020__ $$a9781493913114$$qelectronic book
000717120 020__ $$a1493913115$$qelectronic book
000717120 020__ $$z9781493913107
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000717120 0247_ $$a10.1007/978-1-4939-1311-4$$2doi
000717120 035__ $$aSP(OCoLC)ocn895254750
000717120 035__ $$a717120
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000717120 08204 $$a571.964$$223
000717120 24500 $$aMacrophages$$h[electronic resource] :$$bbiology and role in the pathology of diseases /$$cSubhra K. Biswas, Alberto Mantovani, editors.
000717120 264_1 $$aNew York :$$bSpringer,$$c2014.
000717120 300__ $$a1 online resource (ix, 615 pages) :$$billustrations
000717120 336__ $$atext$$btxt$$2rdacontent
000717120 337__ $$acomputer$$bc$$2rdamedia
000717120 338__ $$aonline resource$$bcr$$2rdacarrier
000717120 5050_ $$aPart I Macrophage: Origin, Activation And Polarization -- Blood monocytes and their subsets in health and disease -- Polarized activation of macrophages -- Alternative activation of macrophages: concepts and prospects -- Regulatory macrophages and the maintenance of homeostasis -- Part II Macrophages And Their Diverse Functions -- Phagocytosis -- The antimicrobial functions of macrophages -- Vascular modulatory functions of macrophages -- Part III Macrophages In Different Tissues -- Airway macrophages: sentinels of health -- Microglial ontogeny and functions in shaping brain circuits -- Kupffer cells in health and disease -- Intestinal Macrophages: Specialized antigen-presenting cells at the front line -- Part IV Macrophages In Pathology -- The wound macrophage -- Macrophages and the entrance of resolution phase lipid mediators -- Macrophages in sepsis progression -- Adaptive characteristics of innate immune responses in macrophages -- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection -- Macrophages in obesity and insulin resistance -- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases -- Myelomonocytic subsets in tumor microenvironment -- Tumor associated macrophages -- Part V Transcriptional And Epigenetic Mechanisms -- Role of NF-kB activation in macrophages -- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation -- Kruppel-like factors in Monocyte-Macrophage Biology -- Regulation of macrophage polarization by the STAT-SOCS signaling axis -- Functions of the large Maf transcription factors and macrophages -- The Control of Gene Expression in Macrophages -- Role of microRNA in macrophage activation and polarization -- Part VI Systems Biology Of Macrophages -- The macrophage transcriptome -- Omics approaches in macrophage biology -- Appendix.
000717120 506__ $$aAccess limited to authorized users.
000717120 520__ $$aMacrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease.
000717120 650_0 $$aMacrophages.
000717120 650_0 $$aMacrophages$$vLaboratory manuals.
000717120 7001_ $$aBiswas, Subhra K.,$$eeditor.
000717120 7001_ $$aMantovani, Alberto,$$eeditor.
000717120 77608 $$iPrint version:$$z9781493913107
000717120 85280 $$bebk$$hSpringerLink
000717120 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://dx.doi.org/10.1007/978-1-4939-1311-4$$zOnline Access
000717120 909CO $$ooai:library.usi.edu:717120$$pGLOBAL_SET
000717120 980__ $$aEBOOK
000717120 980__ $$aBIB
000717120 982__ $$aEbook
000717120 983__ $$aOnline
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