@article{720989,
      recid = {720989},
      author = {Berger, Adam C., and Olson, Steve,},
      title = {Genome-based therapeutics targeted drug discovery and  development : workshop summary / [electronic resource] :},
      pages = {1 online resource (109 pages) :},
      abstract = {"The number of new drug approvals has remained reasonably  steady for the past 50 years at around 20 to 30 per year,  while at the same time the total spending on health-related  research and development has tripled since 1990. There are  many suspected causes for this trend, including increases  in regulatory barriers, the rising costs of scientific  inquiry, a decrease in research and development efficiency,  the downstream effects of patient expirations on  investment, and the lack of production models that have  successfully incorporated new technology. Regardless, this  trajectory is not economically sustainable for the  businesses involved, and, in response, many companies are  turning toward collaborative models of drug development,  whether with other industrial firms, academia, or  government. Introducing greater efficiency and knowledge  into these new models and aligning incentives among  participants may help to reverse the trends highlighted  above, while producing more effective drugs in the process.  Genome-based therapeutics explains that new technologies  have the potential to open up avenues of development and to  identify new drug targets to pursue. Specifically, improved  validation of gene-disease associations through genomics  research has the potential to revolutionize drug production  and lower development costs. Genetic information has helped  developers by increasing their understanding of the  mechanisms of disease as well as individual patients'  reactions to their medications. There is a need to identify  the success factors for the various models that are being  developed, whether they are industry-led, academia-led, or  collaborations between the two. Genome-Based Therapeutics  summarizes a workshop that was held on March 21, 2012,  titled New paradigms in drug discovery: how genomic data  are being used to revolutionize the drug discovery and  development process. At this workshop the goal was to  examine the general approaches being used to apply  successes achieved so far, and the challenges  ahead"--Publisher's description.},
      url = {http://library.usi.edu/record/720989},
}