Applied pharmacometrics [electronic resource] / Stephan Schmidt, Hartmut Derendorf, editors.
Schmidt, Stephan.; Derendorf, Hartmut.
2014
RS187
Available Online

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Title Applied pharmacometrics [electronic resource] / Stephan Schmidt, Hartmut Derendorf, editors.
ISBN 9781493913046 electronic book
1493913042 electronic book
9781493913039
DOI https://doi.org/10.1007/978-1-4939-1304-6
Published New York : Springer, 2014.
Language English
Description 1 online resource.
Item Number 10.1007/978-1-4939-1304-6 doi
Call Number RS187
Dewey Decimal Classification 615/.1
Summary This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimer?s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection. Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource ; title from PDF title page (viewed on December 18, 2014).
Added Author Schmidt, Stephan.
Derendorf, Hartmut.
Series AAPS advances in the pharmaceutical sciences series ; 14.
Available in Other Form Print version: 9781493913039
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Record Appears in Online Resources > Ebooks
All Resources
1 Introduction to Pharmacometrics and Quantitative Pharmacology with an Emphasis on Physiologically Based Pharmacokinetics
2 Personalized Medicine ? Integrating Individual Exposure and Response Information at the Bedside
3 Pharmacometrics in Pediatrics
4 Pharmacometrics in Chronic Kidney Disease
5 Drug-Disease Model-Based Development of Therapeutic Agents for Treatment of Diabetes
6 Applied Pharmacometrics in the Obese Population
7 Pharmacometrics in Cardiovascular Safety
8 Pharmacometrics in Bacterial Infections
9 Pharmacometrics in Viral Infections
10 Applied Antifungal Pharmacometrics: Fluconazole and Echinocandins in the Treatment of Candidemia and Invasive Candidiasis
11 Pharmacometrics and Tuberculosis
12 Pharmacometrics in Pulmonary Diseases
13 State-of-the-Art Pharmacometric Models in Osteoporosis
14 Pharmacometrics in Psychiatric Diseases
15 Clinical Trial Simulation in Alzheimer?s Disease
16 Pharmacometric Applications in Inflammation
17 Pharmacometrics in Dermatology
18 Pharmacometrics in Pain Management
19 Pharmacometrics of Hyperlipidemia.

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