000722754 000__ 04485cam\a2200493Ii\4500 000722754 001__ 722754 000722754 005__ 20230306140241.0 000722754 006__ m\\\\\o\\d\\\\\\\\ 000722754 007__ cr\un\nnnunnun 000722754 008__ 141209s2014\\\\nyu\\\\\ob\\\\001\0\eng\d 000722754 020__ $$a9781493920952$$qelectronic book 000722754 020__ $$a1493920952$$qelectronic book 000722754 020__ $$z9781493920945 000722754 020__ $$z1493920944 000722754 0247_ $$a10.1007/978-1-4939-2095-2$$2doi 000722754 035__ $$aSP(OCoLC)ocn897810372 000722754 035__ $$aSP(OCoLC)897810372 000722754 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dYDXCP$$dCUS$$dE7B$$dCOO$$dCDX$$dGW5XE$$dOCLCF 000722754 049__ $$aISEA 000722754 050_4 $$aQP91 000722754 08204 $$a612.11$$223 000722754 24502 $$aA systems biology approach to blood$$h[electronic resource] /$$cSeth J. Corey, Marek Kimmel, Joshua N. Leonard, editors. 000722754 264_1 $$aNew York :$$bSpringer,$$c[2014] 000722754 264_4 $$c©2014 000722754 300__ $$a1 online resource. 000722754 336__ $$atext$$btxt$$2rdacontent 000722754 337__ $$acomputer$$bc$$2rdamedia 000722754 338__ $$aonline resource$$bcr$$2rdacarrier 000722754 4901_ $$aAdvances in experimental medicine and biology ;$$vvolume 844 000722754 504__ $$aIncludes bibliographical references and index. 000722754 5050_ $$aPart I: Basic Components -- Systems Hematology: An Introduction -- Quantification and Modeling of Stem Cell -- Niche Interaction -- Angiogenesis: A Systems Biology View of Blood Vessel Remodeling -- Erythropoiesis: From Molecular Pathways to System Properties -- Systems Biology of Megakaryocytes -- Systems Biology of Platelet-Vessel Wall Interactions -- Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes -- Part II: Physiological Processes -- Stochasticity and Determinism in Models of Hematopoiesis -- Systems Analysis of High?Throughput Data -- Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control -- A Systems Biology Approach to Iron Metabolism -- Innate Immunity in Disease -- Insights from Mathematical Modeling and Analysis -- Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems -- Structure and Function of Platelet Receptors Initiating Blood Clotting -- Part III: Clinical Applications -- Understanding and Treating Cytopenia through Mathematical Modeling -- Drug Resistance -- Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models -- Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure -- Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine -- Part IV: Epilogue -- A Systems Approach to Blood Disorders -- Index. 000722754 506__ $$aAccess limited to authorized users. 000722754 520__ $$aThe blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks. 000722754 650_0 $$aBlood. 000722754 650_0 $$aSystems biology. 000722754 7001_ $$aCorey, Seth J.,$$eeditor. 000722754 7001_ $$aKimmel, Marek,$$eeditor. 000722754 7001_ $$aLeonard, Joshua N.,$$eeditor. 000722754 77608 $$iPrint version:$$z9781493920945 000722754 830_0 $$aAdvances in experimental medicine and biology ;$$vvolume 844. 000722754 852__ $$bebk 000722754 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-2095-2$$zOnline Access$$91397441.1 000722754 909CO $$ooai:library.usi.edu:722754$$pGLOBAL_SET 000722754 980__ $$aEBOOK 000722754 980__ $$aBIB 000722754 982__ $$aEbook 000722754 983__ $$aOnline 000722754 994__ $$a92$$bISE