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000722872 020__ $$a9783319119854$$qelectronic book
000722872 020__ $$a3319119850$$qelectronic book
000722872 020__ $$z9783319119847
000722872 035__ $$aSP(OCoLC)ocn900942748
000722872 035__ $$aSP(OCoLC)900942748
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000722872 049__ $$aISEA
000722872 050_4 $$aQP623.5
000722872 08204 $$a572.88$$223
000722872 24500 $$aTranscriptomics in health and disease$$h[electronic resource] /$$cGeraldo A. Passos, editor.
000722872 264_1 $$aCham :$$bSpringer,$$c[2014]
000722872 264_4 $$c©2014
000722872 300__ $$a1 online resource :$$billustrations (chiefly color)
000722872 336__ $$atext$$btxt$$2rdacontent
000722872 337__ $$acomputer$$bc$$2rdamedia
000722872 338__ $$aonline resource$$bcr$$2rdacarrier
000722872 504__ $$aIncludes bibliographical references and index.
000722872 5050_ $$aPart 1: Basic Principles of the Transcriptome and its Analysis -- What is the Transcriptome and how it is Evaluated? -- Transcriptome Analysis Throughout RNA-seq -- Identification of Biomarkers and Expression Signatures -- Methods for Gene Co-expression Network Visualization and Analysis -- Posttranscriptional Control During Stem Cells Differentiation -- Transcriptome Analysis During Normal Human Mesenchymal Stem Cell Differentiation -- Part II: Transcriptome in Disease -- Thymus Gene Co-expression Networks: A comparative study in children with and without down syndrome -- Transcriptome Profiling in Autoimmune Diseases -- Expression of DNA Repair and Response to Oxidative Stress Genes in Diabetes Mellitus -- MicroRNAs in Cancer -- Transcriptome Profiling in Chronic Inflammatory Diseases of the Musculoskeletal System -- Transcriptome Profiling in Experimental Inflammatory Arthritis -- Transcriptome in Human Mycoses -- Transcriptomics of the Host-pathogen Interaction in Paracoccidioidomycosis -- Dissecting Tuberculosis through Transcriptomic Studies -- Understanding chagas Disease by Genome and Transcriptome Exploration -- Expression Tests in Actual Clinical Practice: How medically useful is the transcriptome? -- Conclusions -- Index.
000722872 506__ $$aAccess limited to authorized users.
000722872 520__ $$aAfter sequencing the human genome a decade ago, researchers have continued their projects, but now to try to better understand how, and when, genes are expressed in health and disease. Efforts have been concentrated on the measurement of the expression of RNA transcripts. In an analogy to the genome, the term "transcriptome" was created to refer to the complete set of RNAs in a cell type or tissue in a particular situation. Transcriptomics is the science that studies this issue and it is a branch of functional genomics. Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it. The authors discuss the concept and use of gene expression signatures and transcriptional biomarkers in normal development and diseased tissues and organs. As the transcriptome changes depending on the pathology, there is also a focus on the variations in the gene expression in different diseases such as autoimmune, inflammation, cancer and infections. This book should be very useful for researchers in molecular biology focusing on gene expression, human genetics, immunology, and genomics.
000722872 588__ $$aDescription based on online resource; title from PDF title page (viewed January 30, 2015).
000722872 650_0 $$aRNA$$xHealth aspects.
000722872 650_0 $$aTranscriptome$$xHealth aspects.
000722872 7001_ $$aPassos, Geraldo A.,$$eeditor.
000722872 852__ $$bebk
000722872 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-11985-4$$zOnline Access$$91397441.1
000722872 909CO $$ooai:library.usi.edu:722872$$pGLOBAL_SET
000722872 980__ $$aEBOOK
000722872 980__ $$aBIB
000722872 982__ $$aEbook
000722872 983__ $$aOnline
000722872 994__ $$a92$$bISE