Mathematical modelling of the cell cycle stress response [electronic resource] / Elahe Radmaneshfar.

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Mathematical modelling of the cell cycle stress response [electronic resource] / Elahe Radmaneshfar.

9783319007441 electronic book
3319007440 electronic book
9783319007434
3319007432
9783319007434
1306165539
9781306165532

Cham : Springer, 2014.

English

1 online resource (xv, 109 pages) : illustrations (some color).

10.1007/978-3-319-00744-1 doi

QH605

The cell cycle is a sequence of biochemical events that are controlled by complex but robust molecular machinery. This enables cells to achieve accurate self-reproduction under a broad range of conditions. Environmental changes are transmitted by molecular signaling networks, which coordinate their actions with the cell cycle. This work presents the first description of two complementary computational models describing the influence of osmotic stress on the entire cell cycle of S. cerevisiae. Our models condense a vast amount of experimental evidence on the interaction of the cell cycle network components with the osmotic stress pathway. Importantly, it is only by considering the entire cell cycle that we are able to make a series of novel predictions which emerge from the coupling between the molecular components of different cell cycle phases. ? The model-based predictions are supported by experiments in S. cerevisiae and, moreover, have recently been observed in other eukaryotes. Furthermore our models reveal the mechanisms that emerge as a result of the interaction between the cell cycle and stress response networks.

Ph.D. University of Aberdeen [2013?]

Includes bibliographical references.

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Description based on online resource; title from PDF title page (SpringerLink, viewed October 14, 2013).

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