Bioinformatics of non small cell lung cancer and the ras proto-oncogene [electronic resource] / Amita Kashyap, D. Bujamma, Naresh Babu M.
Kashyap, Amita, author.; Bujamma, D., author.; M., Naresh Babu (Muppalaneni), author.
2015
QP531
Available Online

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Title Bioinformatics of non small cell lung cancer and the ras proto-oncogene [electronic resource] / Amita Kashyap, D. Bujamma, Naresh Babu M.
Author Kashyap, Amita, author.
ISBN 9789814585088 electronic book
9814585084 electronic book
9789814585071
DOI https://doi.org/10.1007/978-981-4585-08-8
Published Heidelberg : Springer-Verlag, [2015]
Copyright ©2015
Language English
Description 1 online resource (vii, 72 pages) : illustrations (some color).
Item Number 10.1007/978-981-4585-08-8 doi
Call Number QP531
Dewey Decimal Classification 572.51
Summary Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed September 17, 2014).
Added Author Bujamma, D., author.
M., Naresh Babu (Muppalaneni), author.
Series SpringerBriefs in applied sciences and technology. Forensic and medical bioinformatics.
Available in Other Form Print version: 9789814585071
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Introduction
Review of Literature
Materials and Methods (Tools and Databases)
Flowchart
Conclusion.-References.

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