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000723623 0247_ $$a10.1007/978-1-4939-0727-4$$2doi
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000723623 24500 $$aGenomic applications in pathology$$h[electronic resource] /$$cGeorge Jabboure Netto, Iris Schrijver, editor.
000723623 264_1 $$aNew York, NY :$$bSpringer,$$c[2014]
000723623 264_4 $$c©2015
000723623 300__ $$a1 online resource (xv, 622 pages) :$$billustrations (some color)
000723623 336__ $$atext$$btxt$$2rdacontent
000723623 337__ $$acomputer$$bc$$2rdamedia
000723623 338__ $$aonline resource$$bcr$$2rdacarrier
000723623 500__ $$aIncludes index.
000723623 5050_ $$aPreface; Contents; Contributors; Part I: Genomic Technologies; Chapter 1: Current Massively Parallel Sequencing Technologies: Platforms and Reporting Considerations; Introduction; Platform Chemistry; Rapid Sequencing Revolution; Enrichment Techniques; Different Tests, Different Outcomes; Analysis; Interpretation and Reporting; Dealing with Incidental Findings; Gene Patents; Follow-up, Reanalysis, and Duty to Recontact; Conclusions; References; Chapter 2: Emerging Next-Generation Sequencing Technologies; Introduction; Advantages of Single-Molecule Sequencing
000723623 5058_ $$aSingle-Molecule Cycle Sequencing Real-Time Single-Molecule Sequencing with Polymerase; Sequencing Through Direct Imaging; Sequencing with Protein Nanopores; Solid-State Nanopore Sequencing; Conclusions; References; Chapter 3: Transcriptome Sequencing (RNA-Seq); Introduction; Microarrays, Tag Methods, and RNA-Seq; Sequencing Platforms; RNA Sequencing; Transcriptome Assembly; Specific RNA-Seq Approaches; Clinical Applications of RNA-Seq; Inherited Conditions; Complex Conditions; Cancer; Clinical Microbiology Applications; Conclusions; References
000723623 5058_ $$aChapter 4: MiRNA Expression AssaysIntroduction; MiRNA in Human Disease; Cancer; Adipogenesis; Cardiovascular Diseases; Autoimmune Diseases; Which Types of Biological Samples Can Be Used for MiRNA Studies?; MiRNA Extraction Protocols; MiRNA Quantity and Quality Control; MiRNA Stability; Advanced Techniques for Examining MiRNA Expression; Northern Blotting; Quantitative Reverse Transcription-Polymerase Chain Reaction; In Situ Hybridization; Microarrays; Next-Generation Sequencing; Data Processing and Normalization; Analysis of MiRNA Function and Gene Interaction
000723623 5058_ $$aMiRNA Mimics and Inhibitors Conclusions; References; Chapter 5: Circulating Tumor Cells: Enrichment and Genomic Applications; Introduction; Enrichment Techniques for CTC; Size-Based Microchips; Affinity-Based Microchips; Other Microchip Methods; Detection Methods; Molecular Characterization of CTC; Cancer Stem Cells; CSC in Dissemination; Epithelial-Mesenchymal Transition; Global Genomic Profiling of CTC; Mutation Analyses of CTC; Transcriptional CTC Profiling; Epigenomic and miRNA Characterization of CTC; Conclusions; References
000723623 5058_ $$aChapter 6: Circulating Cell-Free DNA for Molecular Diagnostics and Therapeutic Monitoring; Introduction; Applications in Maternal-Fetal Medicine; Applications in Cancer Diagnostics; ccfDNA Detection Technologies; BEAMing; Droplet Digital PCR; Microfluidic Based Digital PCR; PARE; Additional Medical Applications of ccfDNA; Conclusions; References; Part II: Practice Related Aspects of Clinical Genomics; Chapter 7: Genomic Pathology: Training for New Technology; Introduction; Integration of Genomic Testing into Clinical Care; Are Physicians Prepared for the Genomic Era?
000723623 506__ $$aAccess limited to authorized users.
000723623 520__ $$aGenomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist's role in interpretation and clinical integration of genomic tests results. Genomic applications for site-
000723623 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 26, 2014).
000723623 650_0 $$aMedical genetics.
000723623 7001_ $$aNetto, George J.,$$eeditor.
000723623 7001_ $$aSchrijver, Iris,$$eeditor.
000723623 77608 $$iPrint version:$$tGenomic Applications in Pathology$$dNew York, NY : Springer New York, c2014$$z9781493907267
000723623 852__ $$bebk
000723623 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-0727-4$$zOnline Access$$91397441.1
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000723623 982__ $$aEbook
000723623 983__ $$aOnline
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