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Foreword; Preface; Contents; Contributors; 1: Breast Cancer Genetics and Risk Assessment; Introduction; Recognizing Risk; Defining Risk; Genetic Counseling; Genetic Testing Process; Testing Logistics; Informed Consent; Test Results and Follow-Up; Inherited Breast Cancer Syndromes; Hereditary Breast and Ovarian Cancer Syndrome; Li-Fraumeni Syndrome [ 88 ]; Cowden Syndrome; Peutz-Jeghers Syndrome; Hereditary Diffuse Gastric Cancer Syndrome; Moderate- and Low-Penetrance Breast Cancer Genes
Group 1: Genes Functionally Related to BRCA1 and BRCA2 (ATM, BARD1, CHEK2, MRE11A, NBN, RAD50, FAM175A)ATM (Ataxia Telangiectasia Mutated); BARD1 (BRCA1-Associated RING Domain 1); CHEK2 (Cell Cycle Checkpoint Kinase 2); MRE11A (Meiotic Recombination 11 Homolog A, S. Cerevisiae); NBN (Nibrin aka NBS1); RAD50; FAM175A (Family with Sequence Similarity 175, Member A aka ABRA1, CCDC98); Group 2: Other Genes in the Fanconi Anemia Pathway That Increase Breast Cancer Risk (BRIP1, PALB2); BRIP1(BRCA-Interacting Protein C-Terminal Helicase 1 or FANCJ)
PALB2 (Partner and Localizer of BRCA2 or FANCN) Group 3: RAD51 Gene Family Members; RAD51 Paralogs; Group 4: Hereditary Colorectal Cancer/Polyposis Genes; Lynch Syndrome and MYH-Associated Polyposis; Summary; References; 2: Screening for Breast Cancer; Introduction; Mammographic Screening for Breast Cancer; Recommendations for Screening for Breast Cancer with Imaging in the USA [ 8 ]; Limitations and Potential Harm from Screening Mammography; Screening Women in Their 40s; Harms of Mammography Screening; Nonmammographic Screening for Breast Cancer
Supplemental Screening with Ultrasound in Women with an Elevated Risk for Breast CancerBreast Ultrasound: Pros and Cons (Table 2.2); Supplemental Screening with Ultrasound in Women with Dense Breasts; Screening by Clinical Breast Exam; Screening by Breast Self-Examination [BSE]; Conclusion; References; 3: Mammography Techniques, Positioning, and Optimizing Image Quality; Introduction; Accreditation of Mammography Programs: Historical Overview; Mammographic Techniques: An Overview; Screening Mammography; Standard Mammographic Projections; Craniocaudal (CC) View
Mediolateral Oblique (MLO) View Additional Views; Diagnostic Mammography; Overview; Additional Views; Spot Compression Views; Magnification Views; Mediolateral (ML) and Lateromedial (LM) Views; Exaggerated Craniocaudal View Laterally (XCCL View); Exaggerated Craniocaudal View Medially (XCCM View); Cleavage View; Rolled Medial and Rolled Lateral Views; Tangential Views; Localization Techniques; Mammographic Evaluation After Breast Augmentation; Breast Implants; Silicone Injections; Mammography Artifacts; Motion; Grid Lines; Deodorant/Antiperspirant; Hair Artifact
Group 1: Genes Functionally Related to BRCA1 and BRCA2 (ATM, BARD1, CHEK2, MRE11A, NBN, RAD50, FAM175A)ATM (Ataxia Telangiectasia Mutated); BARD1 (BRCA1-Associated RING Domain 1); CHEK2 (Cell Cycle Checkpoint Kinase 2); MRE11A (Meiotic Recombination 11 Homolog A, S. Cerevisiae); NBN (Nibrin aka NBS1); RAD50; FAM175A (Family with Sequence Similarity 175, Member A aka ABRA1, CCDC98); Group 2: Other Genes in the Fanconi Anemia Pathway That Increase Breast Cancer Risk (BRIP1, PALB2); BRIP1(BRCA-Interacting Protein C-Terminal Helicase 1 or FANCJ)
PALB2 (Partner and Localizer of BRCA2 or FANCN) Group 3: RAD51 Gene Family Members; RAD51 Paralogs; Group 4: Hereditary Colorectal Cancer/Polyposis Genes; Lynch Syndrome and MYH-Associated Polyposis; Summary; References; 2: Screening for Breast Cancer; Introduction; Mammographic Screening for Breast Cancer; Recommendations for Screening for Breast Cancer with Imaging in the USA [ 8 ]; Limitations and Potential Harm from Screening Mammography; Screening Women in Their 40s; Harms of Mammography Screening; Nonmammographic Screening for Breast Cancer
Supplemental Screening with Ultrasound in Women with an Elevated Risk for Breast CancerBreast Ultrasound: Pros and Cons (Table 2.2); Supplemental Screening with Ultrasound in Women with Dense Breasts; Screening by Clinical Breast Exam; Screening by Breast Self-Examination [BSE]; Conclusion; References; 3: Mammography Techniques, Positioning, and Optimizing Image Quality; Introduction; Accreditation of Mammography Programs: Historical Overview; Mammographic Techniques: An Overview; Screening Mammography; Standard Mammographic Projections; Craniocaudal (CC) View
Mediolateral Oblique (MLO) View Additional Views; Diagnostic Mammography; Overview; Additional Views; Spot Compression Views; Magnification Views; Mediolateral (ML) and Lateromedial (LM) Views; Exaggerated Craniocaudal View Laterally (XCCL View); Exaggerated Craniocaudal View Medially (XCCM View); Cleavage View; Rolled Medial and Rolled Lateral Views; Tangential Views; Localization Techniques; Mammographic Evaluation After Breast Augmentation; Breast Implants; Silicone Injections; Mammography Artifacts; Motion; Grid Lines; Deodorant/Antiperspirant; Hair Artifact