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Preface; Contents; Contributors; Introduction; Synthetic Biology as Late-Modern Technology; Abstract ; 1 Introduction: A New Technoscientific Wave?; 2 Characterizing the Field: What Is "Synthetic Biology"?; 3 Self-organization as a Common Denominator of Synthetic Biology; 4 A Visionary Promise: Towards a "Late-Modern Technology"?; 5 What Is Self-organization? Instability as the Core of Late-Modern Technology; 6 The Unknowable: The Inherent Dialectic of Late-Modern Technology; 7 Challenges to Procedures of a Prospective Science and Technology Assessment; 8 Summary; References
Synthetic Biology at the Limits of Science Abstract ; 1 Introduction; 2 Familiar Concepts, Divergent Meanings; 2.1 Creating Understanding; 2.2 Engineering Principles; 2.3 Intelligent Design; 3 From Systems Biology to Synthetic Biology; 3.1 Sublime Thinking; 3.2 Technical Opportunities; 3.3 (Techno)Scientific Biology; 4 Scenes of Conflict; 4.1 Accommodating Ignorance; 4.2 Discontinuous Continuities; 4.3 The Matter of Definition; 5 Conclusion; References; Complexity in Synthetic Biology: Unnecessary or Essential? ; Abstract ; 1 Introduction; 2 Getting Rid of Complexity
3 Different Strategies to Reduce Complexity; 4 Standardization and Modularization; 5 Orthogonalization and the "Genetic Firewall"; 6 Safety Aspects; 6.1 Safety by Computability and Predictability; 6.2 Safety by Genetic Isolation '...the Farther, the Safer'; 7 Which Risk Remains?; References; Characterizing Synthetic Biology Through Its Novel and Enhanced Functionalities ; Abstract ; 1 Introduction; 2 Definitions; 2.1 Functionality; 2.2 Organizational Levels of Biological Objects; 2.3 Synthetic-Biological Approaches; 3 Specific Approaches; 3.1 Nucleic Acids, Amino Acids, and Proteins (Level 1)
3.1.1 DNA Nano-Structures and Nano-Components; 3.1.2 Novel Nucleotides and Nucleic Acids; 3.1.3 RNA Design; 3.1.4 Novel Amino Acids; 3.1.5 Computational Protein Design; 3.2 Genetic Modules and Circuits (Level 2); 3.2.1 Metabolic Engineering of Gene Clusters; 3.2.2 Systems-Biological Construction; 3.3 Genome (Level 3); 3.3.1 Minimal Genomes Through Reduction; 3.3.2 DNA Synthesis; 3.4 Cell (Level 4); 3.4.1 Minimal Cells; 3.4.2 Protocells; 3.4.3 Micro-Nano-Reactors; 4 Combinations of Specific Approaches and Potential Applications
4.1 Combining Novel Molecular Building Blocks with Genetic Modifications and De-Novo Creation; 4.1.1 DNA (Genes); 4.1.2 DNA (Nano-Structures and Nano-Components); 4.1.3 RNA; 4.1.4 Peptides and Proteins; 4.1.5 Standardization and Modularization; 4.2 Design of Signaling and Metabolic Pathways; 4.3 Synthetic and Semi-Synthetic Cells; 5 Potential Risks Derived from Synthetic-Biological Functionalities; 6 Conclusions; References; Synthetic Biology: The Next Step Forward for Industrial Biotechnology ; Abstract ; 1 Introduction; 2 Major Products and Emerging Markets for Industrial Biotechnology
Synthetic Biology at the Limits of Science Abstract ; 1 Introduction; 2 Familiar Concepts, Divergent Meanings; 2.1 Creating Understanding; 2.2 Engineering Principles; 2.3 Intelligent Design; 3 From Systems Biology to Synthetic Biology; 3.1 Sublime Thinking; 3.2 Technical Opportunities; 3.3 (Techno)Scientific Biology; 4 Scenes of Conflict; 4.1 Accommodating Ignorance; 4.2 Discontinuous Continuities; 4.3 The Matter of Definition; 5 Conclusion; References; Complexity in Synthetic Biology: Unnecessary or Essential? ; Abstract ; 1 Introduction; 2 Getting Rid of Complexity
3 Different Strategies to Reduce Complexity; 4 Standardization and Modularization; 5 Orthogonalization and the "Genetic Firewall"; 6 Safety Aspects; 6.1 Safety by Computability and Predictability; 6.2 Safety by Genetic Isolation '...the Farther, the Safer'; 7 Which Risk Remains?; References; Characterizing Synthetic Biology Through Its Novel and Enhanced Functionalities ; Abstract ; 1 Introduction; 2 Definitions; 2.1 Functionality; 2.2 Organizational Levels of Biological Objects; 2.3 Synthetic-Biological Approaches; 3 Specific Approaches; 3.1 Nucleic Acids, Amino Acids, and Proteins (Level 1)
3.1.1 DNA Nano-Structures and Nano-Components; 3.1.2 Novel Nucleotides and Nucleic Acids; 3.1.3 RNA Design; 3.1.4 Novel Amino Acids; 3.1.5 Computational Protein Design; 3.2 Genetic Modules and Circuits (Level 2); 3.2.1 Metabolic Engineering of Gene Clusters; 3.2.2 Systems-Biological Construction; 3.3 Genome (Level 3); 3.3.1 Minimal Genomes Through Reduction; 3.3.2 DNA Synthesis; 3.4 Cell (Level 4); 3.4.1 Minimal Cells; 3.4.2 Protocells; 3.4.3 Micro-Nano-Reactors; 4 Combinations of Specific Approaches and Potential Applications
4.1 Combining Novel Molecular Building Blocks with Genetic Modifications and De-Novo Creation; 4.1.1 DNA (Genes); 4.1.2 DNA (Nano-Structures and Nano-Components); 4.1.3 RNA; 4.1.4 Peptides and Proteins; 4.1.5 Standardization and Modularization; 4.2 Design of Signaling and Metabolic Pathways; 4.3 Synthetic and Semi-Synthetic Cells; 5 Potential Risks Derived from Synthetic-Biological Functionalities; 6 Conclusions; References; Synthetic Biology: The Next Step Forward for Industrial Biotechnology ; Abstract ; 1 Introduction; 2 Major Products and Emerging Markets for Industrial Biotechnology