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Foreword; Preface; Contents; 1: Epidemiology of ESCC; 1.1 Esophageal Cancer in the World and Japan; 1.1.1 Esophageal Cancer in the World: Burden, Geographical Difference, and Trends; 1.1.1.1 Global Burden and Geographical Difference [1]; 1.1.1.2 Histological Type [2]; 1.1.2 Esophageal Cancer in Japan; 1.2 Risk Factors; 1.2.1 Tobacco Smoking and Alcohol Consumption; 1.2.2 Genetic Susceptibility to Tobacco Smoking and Alcohol Drinking; 1.2.3 Fruit and Vegetable Intake; 1.2.4 Mate and Hot Beverages; 1.2.5 Causes of Esophageal Cancer in Japan; References

2: Pathology of Esophageal Squamous Cell Carcinoma2.1 Definitions; 2.2 Macroscopic Features; 2.2.1 Handling of Specimens; 2.2.2 General Features; 2.2.3 Superficial Esophageal Cancer; 2.2.4 Advanced Esophageal Cancer; 2.2.5 Multicentric Squamous Cell Carcinoma (Field Cancerization); 2.2.6 Risk Factors; 2.3 Microscopic Features; 2.4 Tumor Spread; 2.4.1 Superficial Esophageal Cancer; 2.4.1.1 Ductal/Glandular Involvement; 2.4.1.2 Diffuse Pagetoid Spread; 2.4.2 Lymph Node Metastasis in Patients with Superficial Esophageal Cancer; 2.4.3 Advanced Esophageal Cancer; 2.4.3.1 Intramural Metastasis

2.4.3.2 Prognostic Factors2.5 Precursor Lesion (Squamous Dysplasia/Intraepithelial Neoplasia); 2.6 Variants; 2.6.1 Basaloid Squamous Carcinoma; 2.6.2 Carcinosarcoma (Sarcomatoid Carcinoma); 2.6.3 Adenosquamous Carcinoma; 2.6.4 Verrucous Carcinoma; 2.6.5 Lymphoepithelioma-Like Carcinoma (Esophageal Carcinoma with Lymphoid Stroma); References; 3: Diagnostic Imaging of the Esophageal Cancer; 3.1 Introduction; 3.2 Anatomy of the Esophagus; 3.2.1 Divisions of the Esophagus; 3.2.2 Zonal Anatomy of the Esophageal Wall; 3.3 T Staging by Imaging; 3.3.1 Barium Esophagography; 3.3.2 EUS; 3.3.3 CT

3.3.3.1 CT Study Protocol and Optimal Phase for the Evaluation3.3.3.2 Diagnostic Criteria of the Esophageal Cancer; Esophageal Wall Thickness; Other Features; 3.3.3.3 Diagnostic Criteria for Tumor Invasion to the Adjacent Structures; Invasion to the Aorta (Defined as T4b); Invasion to the Tracheobronchial Tree (Defined as T4b); Invasion to the Other Structures; 3.3.4 MRI; 3.3.5 PET; 3.4 N Staging by Imaging; 3.5 M Staging by Imaging; 3.6 Follow-Up; References; 4: Endoscopic Diagnosis of Squamous Cell Carcinoma of the Esophagus; 4.1 Endoscopic Imaging of the Esophagus and ESCC

4.2 Endoscopic Detection and Differential Diagnosis of Superficial ESCC4.2.1 Conventional White Light Imaging; 4.2.2 Lugol Chromoendoscopy; 4.2.3 Equipment-Based Image-Enhanced Endoscopy (IEE); 4.3 Estimation of the Depth of Invasion of Superficial ESCC; 4.3.1 Conventional WLI; 4.3.2 Lugol Chromoendoscopy; 4.3.3 Equipment-Based IEE; 4.3.4 Endoscopic Ultrasound; 4.3.5 Optical Coherence Tomography (OCT); 4.4 Endoscopic Diagnosis of Advanced Esophageal Cancer; 4.5 Differential Diagnosis of Squamous Cell Carcinoma and Adenocarcinoma; 4.6 Histological Confirmation by Biopsy; 4.7 Virtual Biopsy

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