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Foreword: United Kingdom; Foreword: United States of America; Preface; Acknowledgments; Contents; Contributors; 1: Historical Perspective of Raynaud's Phenomenon; Key Points; Milestones; Pathogenetic Mechanisms; Epidemiology; Diagnosis; Treatment; Conclusion; References; 2: Definition, Nomenclature, and Diagnostic Criteria; Key Points; Definition; Nomenclature; Criteria for Classification; Diagnostic Criteria; Summary; References; 3: Epidemiology of Raynaud's Phenomenon; Key Points; Primary RP; Incidence and Prevalence of Primary RP; Risk Factors for Primary RP; Age; Female Sex
Environmental Factors Genetic Factors (Including for Secondary RP); Secondary RP; Incidence and Prevalence of Secondary RP; Aetiology of Secondary RP; Systemic Sclerosis; Other Autoimmune Diseases; Other Systemic Diseases; Neurologic Diseases; Drugs (Chap. 10); Occupational Exposure to Vibration (Chap. 9); Risk and Prognostic Factors for Progression to Systemic Disease; RP as Risk Factor for Digital Ischemia, Gangrene and Auto-amputation; RP as Risk Factor for Other Organ Manifestations; Morbidity and Function; Expert Opinion; Conclusions; References
4: Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular SystemKey Points; Introduction; General Aspects of the Vascular System and Blood Vessel Wall; Structural and Functional Organization of the Human Cutaneous Circulation; Mechanisms Regulating Blood Flow Responses During Cold Exposure; Modulation of Sympathetic and Adrenergic Constriction; Preclinical Models; The Human Circulation; Secondary Vasomotor Mechanisms; Transient Receptor Potential (TRP) Channels; Brown and Perivascular Adipose Tissue; Gender-Dependent Changes in Cold-Induced Vasoconstriction
6: Primary Raynaud's PhenomenonKey Points; Introduction; Case History; Definition; Epidemiology; Pathogenesis; History and Examination; Investigations; Treatment; Patient Education/General Measures; Drug Treatment (Table 6.2); Other Treatments; Transition from Primary to Secondary RP; Expert Opinion; References; 7: Raynaud Phenomenon in the Pediatric Age; Key Points; Introduction; Epidemiology Including Secondary Causes; Clinical Features; History; Examination; Investigations; Nailfold Capillaroscopy in Children; Other Imaging Techniques; Predictors of Progression to CTD
Environmental Factors Genetic Factors (Including for Secondary RP); Secondary RP; Incidence and Prevalence of Secondary RP; Aetiology of Secondary RP; Systemic Sclerosis; Other Autoimmune Diseases; Other Systemic Diseases; Neurologic Diseases; Drugs (Chap. 10); Occupational Exposure to Vibration (Chap. 9); Risk and Prognostic Factors for Progression to Systemic Disease; RP as Risk Factor for Digital Ischemia, Gangrene and Auto-amputation; RP as Risk Factor for Other Organ Manifestations; Morbidity and Function; Expert Opinion; Conclusions; References
4: Thermoregulation: The Normal Structure and Function of the Cutaneous Vascular SystemKey Points; Introduction; General Aspects of the Vascular System and Blood Vessel Wall; Structural and Functional Organization of the Human Cutaneous Circulation; Mechanisms Regulating Blood Flow Responses During Cold Exposure; Modulation of Sympathetic and Adrenergic Constriction; Preclinical Models; The Human Circulation; Secondary Vasomotor Mechanisms; Transient Receptor Potential (TRP) Channels; Brown and Perivascular Adipose Tissue; Gender-Dependent Changes in Cold-Induced Vasoconstriction
6: Primary Raynaud's PhenomenonKey Points; Introduction; Case History; Definition; Epidemiology; Pathogenesis; History and Examination; Investigations; Treatment; Patient Education/General Measures; Drug Treatment (Table 6.2); Other Treatments; Transition from Primary to Secondary RP; Expert Opinion; References; 7: Raynaud Phenomenon in the Pediatric Age; Key Points; Introduction; Epidemiology Including Secondary Causes; Clinical Features; History; Examination; Investigations; Nailfold Capillaroscopy in Children; Other Imaging Techniques; Predictors of Progression to CTD