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000723958 019__ $$a908090279
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000723958 24500 $$aMetabonomics and gut microbiota in nutrition and disease$$h[electronic resource] /$$cSunil Kochhar, François-Pierre Martin, editors.
000723958 264_1 $$aLondon :$$bSpringer,$$c[2014]
000723958 264_4 $$c©2015
000723958 300__ $$a1 online resource (xvi, 375 pages) :$$billustrations (some color).
000723958 336__ $$atext$$btxt$$2rdacontent
000723958 337__ $$acomputer$$bc$$2rdamedia
000723958 338__ $$aonline resource$$bcr$$2rdacarrier
000723958 4901_ $$aMolecular and Integrative Toxicology,$$x2168-4219
000723958 500__ $$aIncludes index.
000723958 5050_ $$aPreface; Contents; Contributors; Editor Biographies; Chapter 1: Introduction to℗ Metabonomics in℗ Systems Biology Research; 1.1 Introduction; 1.2 Metabonomics-Based Systems Approaches: Lessons Learnt and℗ Highlights; 1.3 Gut Microbiota Metabolism in℗ Nutrition, Health, and℗ Disease; 1.4 System Biology Approaches: Applications with℗ Specific Reference to℗ Gut Microbial Metabolic Interactions; 1.5 Novel Directions and℗ Perspectives; References; Chapter 2: Metabonomics in℗ Clinical Practice; 2.1 Introduction; 2.2 State-of-the-Art Metabonomics and℗ Lipidomics Technologies
000723958 5058_ $$a2.3 Metabonomics Flow Chart in℗ Epidemiological Studies2.4 Clinical Applications of℗ Metabonomics for℗ Aging Biomarkers; 2.5 Clinical Application of℗ Metabonomics for℗ Biomarkers of℗ Metabolic Syndrome; 2.6 Clinical Application for℗ Neurological and℗ Psychiatric Disorders; 2.7 Clinical Applications for℗ Cancer Diagnosis; 2.8 Conclusion; References; Chapter 3: Adopting Multivariate Nonparametric Tools to℗ Determine Genotype-Phenotype Interactions in℗ Health and℗ Disease; 3.1 Metabolomics: Introducing the℗ Paradigm Shift in℗ Data Analysis; 3.2 Expanding the℗ View: Machine Learning
000723958 5058_ $$a3.3 Data Structure and℗ Inference: Classification and℗ Regression Trees (CART)3.4 Ensemble Classifiers: From℗ Single Trees to℗ Random Forests; 3.5 Recent Contributions from℗ RF in℗ the℗ Metabolome-℗ƯMicrobiome Arena; 3.6 Integration Between Information Sources: RF and℗ Networks; 3.7 Application-Driven Improvements to℗ RF Scheme; 3.8 New Challenges to℗ RF:℗ Network Inference; 3.9 Conclusions and℗ Perspective; References; Chapter 4: Metabonomics in℗ Translational Research for℗ Personalized Medicine and℗ Nutrition; 4.1 Metabolomics and℗ Metabonomics; 4.2 Metabonomics: The℗ Link Between Genotypes and℗ Phenotypes
000723958 5058_ $$a4.3 Role of℗ Pharmacometabonomics in℗ Personalized Medicine4.4 Methodologies Used in℗ Metabonomics; 4.5 Metabonomic Technologies for℗ Toxicology Studies; 4.6 Metabonomics and℗ Personalized Nutrition; 4.7 Gut Microbiota and℗ Phytochemical Profiling in℗ Nutrition Science; 4.8 The Importance of℗ the℗ Gut Microbiota on℗ Metabolic Profiles; 4.9 Conclusion and℗ Future Perspectives; References; Chapter 5: Can We℗ Use Metabolomics to℗ Understand Changes to℗ Gut Microbiota Populations and℗ Function? A℗ Nutritional Perspective; 5.1 Introduction; 5.2 Colonic Digestion; 5.3 Gut Modulation by Foods and℗ Diet
000723958 5058_ $$a5.3.1 How Do Different Foods Alter Gut Microbiota and℗ Their Metabolism?5.3.2 Microbial Metabolism and℗ a℗ Carbohydrate-Rich Diet; 5.3.3 Fat-Rich Diet Interactions with℗ Gut Microbiota; 5.3.4 Choline Metabolism: An℗ Interaction Node Between Diet, Host, and℗ Gut Microbiota?; 5.3.5 Protein-Rich Diets and℗ Gut Microbiota; 5.3.6 Interaction of℗ a℗ Polyphenol-Rich Diet with℗ the℗ Gut Microbiota; 5.4 Nutritional Metabolomics: A℗ Methodology Well Suited for℗ Understanding the℗ Effects of℗ Food on℗ Gut Microbiota; 5.4.1 Metabolomics Methods to℗ Study Gut Activity Effects on℗ Metabolism; 5.5 Metabolites of℗ Gut Activity
000723958 506__ $$aAccess limited to authorized users.
000723958 520__ $$aThis book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition. The rise in multifactorial disorders, the lack of understanding of the mol.
000723958 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 10, 2014).
000723958 650_0 $$aDigestive organs$$xMicrobiology.
000723958 650_0 $$aSystems biology.
000723958 7001_ $$aKochhar, Sunil,$$eeditor.
000723958 7001_ $$aMartin, François-Pierre,$$eeditor.
000723958 77608 $$iPrint version:$$aKochhar, Sunil$$tMetabonomics and Gut Microbiota in Nutrition and Disease$$dLondon : Springer London,c2014$$z9781447165385
000723958 830_0 $$aMolecular and integrative toxicology.
000723958 85280 $$bebk$$hSpringerLink
000723958 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4471-6539-2$$zOnline Access$$91397441.1
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000723958 980__ $$aBIB
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000723958 983__ $$aOnline
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