The mechanobiology of obesity and related diseases [electronic resource] / Amit Gefen, Dafna Benayahu, editors.
Gefen, Amit, editor.; Benayahu, Dafna, editor.
2015
QP303
Available Online

Linked e-resources

Linked Resource Online Access
Concurrent users Unlimited
Authorized users Authorized users
Document Delivery Supplied Can lend chapters, not whole ebooks

Details

Title The mechanobiology of obesity and related diseases [electronic resource] / Amit Gefen, Dafna Benayahu, editors.
ISBN 9783319093369 electronic book
3319093363 electronic book
9783319093352
DOI https://doi.org/10.1007/978-3-319-09336-9
Published Cham : Springer, [2015]
Copyright ©2015
Language English
Description 1 online resource (x, 296 pages).
Item Number 10.1007/978-3-319-09336-9 doi
Call Number QP303
Dewey Decimal Classification 612/.01441
Summary This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed November 7, 2014).
Added Author Gefen, Amit, editor.
Benayahu, Dafna, editor.
Series Studies in mechanobiology. tissue engineering. and biomaterials ; volume 16.
Available in Other Form Print version: 9783319093352
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Mechanical behavior and properties of adipose tissue
Mathematical models of adipose tissue dynamics
Mechanical stretching and signaling pathways in adipogenesis- Role of mechanical stimulations in directing mesenchymal stem cell adipogenesis
The vicious cycle of estrogen consumption and obesity: The role of mechanotransduction
Extracellular matrix remodeling and mechanical stresses as modulators of adipose tissue metabolism and inflammation
The Impact of Obesity and Weight Loss on Gait in Adults
Excessive Weight Bearing Compromises Foot Structure and Function across the Lifespan
Obesity, Osteoarthritis and Aging: The Biomechanical Links
Impaired neutrophil mechanoregulation by fluid flow: A potential contributing factor for microvascular dysfunction in obesity
Mechanotransduction and the myogenic response in diabetes
Role of adipose cells in tumor microenvironment.

Browse Subjects

Show more subjects...

Statistics

from
to
Export