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Preface; Contents; Contributors; 1: Pathophysiology of Uterine Myomas and Its Clinical Implications; Introduction; Prevalence and Histogenesis; Factors Influencing Growth of Leiomyomas; Estrogens (E); Progesterone (P); Growth Factors; Cytogenetics; High Mobility Group 1 Proteins; Uterine Inner and Outer Myometrium; Vascularization and Location of Uterine Myomas; Symptomatology of Uterine Myomas; Abnormal Uterine Bleeding; Infertility; Spontaneous Abortions; Pelvic Pain; Promising New Medical Therapeutic Agents; Progesterone Antagonists; Selective Progesterone Receptor Modulators (SPRMs)
AsoprisnilProellex (CDB-4124); Ulipristal Acetate (CDB-2914); Aromatase Inhibitors (AIs); Summary and Conclusions; References; 2: Genetic and Genomics of Uterine Myomas; Introduction; Molecular Aspect of Uterine Leiomyomas; The Genomic Landscape of Uterine Myomas: Mutation Analysis and Chromosome Rearrangements; Epigenetics in Myomas; Pathways Influencing Disease; Perspectives; References; 3: Uterine Myomas and Histopathology; Introduction; Particular Types of Leiomyomata; STUMP; References; 4: Uterine Fibroids: Clinical Features; Introduction; Incidence; Risk Factors; Clinical Presentation
Natural History of FibroidsDiagnosis; Treating Pre-operative Anemia; New Appearance of Fibroids; Uterine Changes Following Myomectomy; The Risk of Uterine Rupture After Myomectomy; References; 5: Uterine Myomas and Fertility; Introduction; Etiology, Pathophysiology and Genetic Origin; Etiology and Microscopy; Pathophysiology; Genetic Origin; Philosophy of Myomas in Infertility; Myomas and Fertility Outcome?; Implantation Rates; Recurrent Pregnancy Loss; Myomas During Pregnancy; Treatment Possibilities; Myomectomy and Fertility: Laparoscopic and Hysteroscopic Resection of Fibroids
General AspectsLaparoscopic Stepwise Enucleation of an Intramural Fibroid and Uterine Reconstruction; Hysteroscopic Myoma Enucleation Has to Be Performed According to the Depth of Infiltration into the Myometrium; Differentiation of Fibroids and Focal Endometriosis to Adenomatoid Tumors; Case 1; Case 2; Recurrence Rates; Fertility Outcome: Our Experience; Location of Myoma; Pregnancies and Deliveries; Mode of Delivery; Complications; Discussion and Conclusions; References; 6: Uterine Fibroid Pseudocapsule; Introduction; Anatomy of Fibroid Pseudocapsule
Neurotransmitters in Myoma PseudocapsuleComparison Between Myoma Pseudocapsule and Prostate Capsule; Intracapsular Myomectomy; The Functional Autonomy of Pseudocapsule and Its Impact on Muscular Healing; The Advantage of Endoscopically Tailored Myomectomy and Prostatectomy; The Rationale of Intracapsular Myomectomy: Pro and Cons; Conclusions; References; 7: Adenomyosis and Adenomyomata; Introduction; Historical Background; Histological Definition; Etiology of Adenomyosis; Diagnostic Methods and the Uterine Junctional Zone; Symptomatology and Types of Adenomyosis
AsoprisnilProellex (CDB-4124); Ulipristal Acetate (CDB-2914); Aromatase Inhibitors (AIs); Summary and Conclusions; References; 2: Genetic and Genomics of Uterine Myomas; Introduction; Molecular Aspect of Uterine Leiomyomas; The Genomic Landscape of Uterine Myomas: Mutation Analysis and Chromosome Rearrangements; Epigenetics in Myomas; Pathways Influencing Disease; Perspectives; References; 3: Uterine Myomas and Histopathology; Introduction; Particular Types of Leiomyomata; STUMP; References; 4: Uterine Fibroids: Clinical Features; Introduction; Incidence; Risk Factors; Clinical Presentation
Natural History of FibroidsDiagnosis; Treating Pre-operative Anemia; New Appearance of Fibroids; Uterine Changes Following Myomectomy; The Risk of Uterine Rupture After Myomectomy; References; 5: Uterine Myomas and Fertility; Introduction; Etiology, Pathophysiology and Genetic Origin; Etiology and Microscopy; Pathophysiology; Genetic Origin; Philosophy of Myomas in Infertility; Myomas and Fertility Outcome?; Implantation Rates; Recurrent Pregnancy Loss; Myomas During Pregnancy; Treatment Possibilities; Myomectomy and Fertility: Laparoscopic and Hysteroscopic Resection of Fibroids
General AspectsLaparoscopic Stepwise Enucleation of an Intramural Fibroid and Uterine Reconstruction; Hysteroscopic Myoma Enucleation Has to Be Performed According to the Depth of Infiltration into the Myometrium; Differentiation of Fibroids and Focal Endometriosis to Adenomatoid Tumors; Case 1; Case 2; Recurrence Rates; Fertility Outcome: Our Experience; Location of Myoma; Pregnancies and Deliveries; Mode of Delivery; Complications; Discussion and Conclusions; References; 6: Uterine Fibroid Pseudocapsule; Introduction; Anatomy of Fibroid Pseudocapsule
Neurotransmitters in Myoma PseudocapsuleComparison Between Myoma Pseudocapsule and Prostate Capsule; Intracapsular Myomectomy; The Functional Autonomy of Pseudocapsule and Its Impact on Muscular Healing; The Advantage of Endoscopically Tailored Myomectomy and Prostatectomy; The Rationale of Intracapsular Myomectomy: Pro and Cons; Conclusions; References; 7: Adenomyosis and Adenomyomata; Introduction; Historical Background; Histological Definition; Etiology of Adenomyosis; Diagnostic Methods and the Uterine Junctional Zone; Symptomatology and Types of Adenomyosis