000724429 000__ 03660cam\a2200469Ii\4500 000724429 001__ 724429 000724429 005__ 20230306140533.0 000724429 006__ m\\\\\o\\d\\\\\\\\ 000724429 007__ cr\cn\nnnunnun 000724429 008__ 141120t20152015ne\a\\\\ob\\\\001\0\eng\d 000724429 019__ $$a900020681$$a908086571 000724429 020__ $$a9789401791687$$qelectronic book 000724429 020__ $$a9401791686$$qelectronic book 000724429 020__ $$z9789401791670 000724429 0247_ $$a10.1007/978-94-017-9168-7$$2doi 000724429 035__ $$aSP(OCoLC)ocn896342538 000724429 035__ $$aSP(OCoLC)896342538$$z(OCoLC)900020681$$z(OCoLC)908086571 000724429 040__ $$aN$T$$beng$$erda$$epn$$cN$T$$dN$T$$dE7B$$dGW5XE$$dYDXCP$$dCOO$$dIDEBK$$dEBLCP 000724429 049__ $$aISEA 000724429 050_4 $$aRB43.8.N83 000724429 08204 $$a616.0756$$223 000724429 24500 $$aCirculating nucleic acids in early diagnosis, prognosis and treatment monitoring$$h[electronic resource] :$$ban introduction /$$cPeter B. Gahan, editor. 000724429 264_1 $$aDordrecht [Netherlands] :$$bSpringer,$$c[2015] 000724429 264_4 $$c©2015 000724429 300__ $$a1 online resource (xix, 471 pages) :$$billustrations (some color). 000724429 336__ $$atext$$btxt$$2rdacontent 000724429 337__ $$acomputer$$bc$$2rdamedia 000724429 338__ $$aonline resource$$bcr$$2rdacarrier 000724429 4901_ $$aAdvances in predictive, preventive and personalised medicine ;$$vvolume 5 000724429 504__ $$aIncludes bibliographical references and indexes. 000724429 5050_ $$aPart I. BACKGROUND -- CHAPTER 1 Introduction -- Brief History and the present and future status of CNAPS -- CHAPTER 2 The biology of CNAPS -- Part II. METHODOLOGY -- CHAPTER 3 Pre-analytical requirements for analysing nucleic acids from blood -- CHAPTER 4. Circulating DNA and miRNA isolation -- CHAPTER 5 Detection of genetic alterations by nucleic acid analysis: use of pcr and mass spectroscopy-based methods -- CHAPTER 6 Genomic approaches to the analysis of cell free nucleic acids -- Part III APPLICATIONS -- CHAPTER 7 CNAPS and General Medicine -- CHAPTER 8 Fetal CNAPS ? DNA/RNA -- CHAPTER 9 Circulating nucleic acids and Diabetes mellitus -- CHAPTER 10 Extracellular nucleic acids and cancer -- CHAPTER 11 Other bodily fluids as non-invasive sources of Cell-free DNA/RNA -- CHAPTER 12 CNAPS in therapy monitoring -- Part IV OTHER ASPECTCS -- CHAPTER 13 Quality Assurance -- CHAPTER 14 Societal Aspects: Ethics. 000724429 506__ $$aAccess limited to authorized users. 000724429 520__ $$aDNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals. Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up. In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids. The areas covered in this volume include: · Background and general biology of circulating nucleic acids · Methodology · Applications of circulating nucleic acids · Quality Assurance · Ethics 000724429 588__ $$aDescription based on online resource; title from PDF title page (viewed December 12, 2014). 000724429 650_0 $$aNucleic acids$$xDiagnostic use. 000724429 7001_ $$aGahan, Peter B.,$$eeditor. 000724429 77608 $$iPrint version:$$z9789401791670 000724429 830_0 $$aAdvances in predictive. preventive and personalised medicine ;$$vv. 5. 000724429 852__ $$bebk 000724429 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-94-017-9168-7$$zOnline Access$$91397441.1 000724429 909CO $$ooai:library.usi.edu:724429$$pGLOBAL_SET 000724429 980__ $$aEBOOK 000724429 980__ $$aBIB 000724429 982__ $$aEbook 000724429 983__ $$aOnline 000724429 994__ $$a92$$bISE