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Acknowledgments; Contents; Contributors; Part I Imaging, Delineation and Immobilization; 1034 MR Imaging and MR Spectroscopy in Prostate Cancer; Abstract; 1 The Role of Magnetic Resonance Imaging (MRI) in the Diagnosis and Therapy Monitoring of Prostate Cancer (PCa); 2 Multiparametric MRI (mp-MRI); 2.1 T2-Weighted Imaging; 2.2 Diffusion-Weighted Imaging (DWI) and the Apparent Diffusion Coefficient (ADC); 2.3 Dynamic-Contrast-Enhanced MRI (DCE-MRI, Perfusion Imaging); 2.4 MR Spectroscopy of Prostate Cancer; 2.4.1 1H-MR Spectrum and Metabolite Signals
2.4.2 1H-MRS Acquisition and Spatial Localization2.4.3 MR Spectroscopic Imaging (MRSI); 2.4.4 MRSI of the Prostate in Radiotherapy Planning and Follow-Up; 3 Summary; References; 1007 PET/CT Imaging in Prostate Cancer: Indications and Perspectives for Radiation Therapy; Abstract; 1...Introduction; 2...Radiotracers; 2.1 11C-Choline, 18F-Choline; 2.2 11C-Acetate; 2.3 18F-Fluorodeoxyglucose (FDG); 2.4 18F-Fluoride; 2.5 Other Tracers; 3...Hardware and Technical Considerations; 4...PET/CT-Imaging of PCa in the primary situation; 4.1 Determining T-Stage; 4.1.1 11C-Choline; 4.1.2 18F-Choline; 4.2 N-Staging
4.2.1 11C-Choline4.2.2 18F-Choline; 4.3 M-Staging; 4.3.1 11C-Choline; 4.3.2 18F-Choline; 5...PET/CT-Imaging of Recurrent PCa; 5.1 11C-Choline; 5.2 18F-Choline; 6...Summary of Data, Recommendations, and Perspectives; 6.1 Primary PCa; 6.2 PSA Recurrence; 6.3 Perspectives in the Situation of Relapse with Locoregional Lymphnode Metastases; 6.4 Therapy Monitoring; 6.5 Closing Remarks; References; 958 Target Volume Definition in Primary Prostate Cancer Radiotherapy; Abstract; 1...Introduction; 2...International Commission on Radiation Units and Measurement (ICRU) Volumes Definition
3...Pathological Considerations for Prostate Cancer Clinical Target Volume Delineation3.1 CTV Delineation in Low-Risk Prostate Cancer; 3.2 CTV Delineation in Intermediate- and High-Risk Prostate Cancer; 4...CT/MRI and Target Delineation; 5...CTV-PTV Margin; References; 1008 Value of Patient Immobilization in External Beam Radiotherapy for Prostate Cancer; Abstract; 1...Introduction; 2...Patient Positioning and External Patient Immobilization; 3...Internal Prostate Immobilization Strategies; 4...Conclusions; References; 917 Internal Immobilization: From Rectal Balloon to Hyaluronic Acid; Abstract
1...Introduction2...Endorectal Balloon; 2.1 Products; 2.2 Application and Patient's Tolerance; 2.3 Immobilization; 2.4 Reproducibility; 2.5 Radioprotection of the Rectum/Rectal Wall; 2.6 Impact on Rectal Toxicity; 2.7 Summary; 3...Rectal Spacer: Hyaluronic Acid (HA), Space OAR Gel, Biodegradable Balloon; 3.1 Products; 3.2 Application; 3.3 Reproducibility/Stability and Radioprotection of the Rectum/ Rectal Wall; 3.4 Summary; References; Part II Clinical Endpoints; 904 Biochemical Recurrence: A Valuable Endpoint?; Abstract; 1...Definition of Biochemical Failure
2.4.2 1H-MRS Acquisition and Spatial Localization2.4.3 MR Spectroscopic Imaging (MRSI); 2.4.4 MRSI of the Prostate in Radiotherapy Planning and Follow-Up; 3 Summary; References; 1007 PET/CT Imaging in Prostate Cancer: Indications and Perspectives for Radiation Therapy; Abstract; 1...Introduction; 2...Radiotracers; 2.1 11C-Choline, 18F-Choline; 2.2 11C-Acetate; 2.3 18F-Fluorodeoxyglucose (FDG); 2.4 18F-Fluoride; 2.5 Other Tracers; 3...Hardware and Technical Considerations; 4...PET/CT-Imaging of PCa in the primary situation; 4.1 Determining T-Stage; 4.1.1 11C-Choline; 4.1.2 18F-Choline; 4.2 N-Staging
4.2.1 11C-Choline4.2.2 18F-Choline; 4.3 M-Staging; 4.3.1 11C-Choline; 4.3.2 18F-Choline; 5...PET/CT-Imaging of Recurrent PCa; 5.1 11C-Choline; 5.2 18F-Choline; 6...Summary of Data, Recommendations, and Perspectives; 6.1 Primary PCa; 6.2 PSA Recurrence; 6.3 Perspectives in the Situation of Relapse with Locoregional Lymphnode Metastases; 6.4 Therapy Monitoring; 6.5 Closing Remarks; References; 958 Target Volume Definition in Primary Prostate Cancer Radiotherapy; Abstract; 1...Introduction; 2...International Commission on Radiation Units and Measurement (ICRU) Volumes Definition
3...Pathological Considerations for Prostate Cancer Clinical Target Volume Delineation3.1 CTV Delineation in Low-Risk Prostate Cancer; 3.2 CTV Delineation in Intermediate- and High-Risk Prostate Cancer; 4...CT/MRI and Target Delineation; 5...CTV-PTV Margin; References; 1008 Value of Patient Immobilization in External Beam Radiotherapy for Prostate Cancer; Abstract; 1...Introduction; 2...Patient Positioning and External Patient Immobilization; 3...Internal Prostate Immobilization Strategies; 4...Conclusions; References; 917 Internal Immobilization: From Rectal Balloon to Hyaluronic Acid; Abstract
1...Introduction2...Endorectal Balloon; 2.1 Products; 2.2 Application and Patient's Tolerance; 2.3 Immobilization; 2.4 Reproducibility; 2.5 Radioprotection of the Rectum/Rectal Wall; 2.6 Impact on Rectal Toxicity; 2.7 Summary; 3...Rectal Spacer: Hyaluronic Acid (HA), Space OAR Gel, Biodegradable Balloon; 3.1 Products; 3.2 Application; 3.3 Reproducibility/Stability and Radioprotection of the Rectum/ Rectal Wall; 3.4 Summary; References; Part II Clinical Endpoints; 904 Biochemical Recurrence: A Valuable Endpoint?; Abstract; 1...Definition of Biochemical Failure