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000724603 0247_ $$a10.1007/978-3-319-09614-8$$2doi
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000724603 050_4 $$aRC268.7.A42$$bB56 2015
000724603 08204 $$a616.99/4071$$223
000724603 24500 $$aBiological basis of alcohol-induced cancer$$h[electronic resource] /$$cVasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek, editors.
000724603 264_1 $$aCham :$$bSpringer,$$c2015.
000724603 300__ $$a1 online resource :$$billustrations.
000724603 336__ $$atext$$btxt$$2rdacontent
000724603 337__ $$acomputer$$bc$$2rdamedia
000724603 338__ $$aonline resource$$bcr$$2rdacarrier
000724603 347__ $$atext file$$bPDF$$2rda
000724603 4901_ $$aAdvances in Experimental Medicine and Biology,$$x0065-2598 ;$$v815
000724603 500__ $$aIncludes index.
000724603 5050_ $$aPreface; Contents; Contributors; Chapter 1: Introduction; References; Chapter 2: Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data; 2.1 Introduction; 2.2 The Biology of Breast Cancer; 2.3 Known Risk Factors for Breast Cancer; 2.4 Alcohol as a Risk Factor for Breast Cancer; 2.4.1 Epidemiological Studies; 2.4.2 Molecular Studies; 2.4.2.1 Estrogen Metabolism; 2.4.2.2 Alcohol Metabolism; 2.4.2.3 Folate Metabolism/Epigenetic Factors; 2.5 Concluding Remarks; 2.5.1 Multiple Risk Factors; 2.5.2 Epidemiological Studies
000724603 5058_ $$a2.5.3 Discrepancies Between Epidemiological and Molecular StudiesReferences; Chapter 3: Genetic-Epidemiological Evidence for the Role of Acetaldehyde in Cancers Related to Alcohol Drinking; 3.1 Introduction; 3.2 General Evidence for the Carcinogenicity of Acetaldehyde; 3.3 Genetic-Epidemiological Evidence for the Carcinogenicity of Acetaldehyde; 3.3.1 Basic Difficulties in Assessing the Genetic-Epidemiological Evidence; 3.3.2 Upper Aerodigestive Tract Cancer; 3.3.3 Gastric Cancer; 3.3.4 Colorectal Cancer; 3.3.5 Pancreatic Cancer; 3.3.6 Liver Cancer; 3.3.7 Lung Cancer; 3.3.8 Breast Cancers
000724603 5058_ $$a3.4 Summary and ConclusionsReferences; Chapter 4: Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P450 2E1; 4.1 Introduction; 4.1.1 Historic Background; 4.1.2 Epidemiology and Animal Experiments; 4.2 Specific Mechanisms of Ethanol-Mediated Carcinogenesis; 4.2.1 Acetaldehyde as a Carcinogen; 4.2.1.1 Mechanisms; 4.2.1.2 Genetic Aspects of Acetaldehyde Accumulation; 4.2.2 Alcohol and Oxidative Stress; 4.2.2.1 Mechanisms of ROS and Cytochrome P450 2E1 in Alcohol-Mediated Carcinogenesis; 4.2.2.2 The Role of CYP2E1 in Experimental Carcinogenesis
000724603 5058_ $$a4.3 CYP2E1 and Its Role in Nonalcoholic Fatty Liver DiseasesReferences; Chapter 5: Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis; 5.1 Introduction; 5.2 DNA Adducts from Acetaldehyde and Alcohol; 5.2.1 Other Acetaldehyde-DNA Adducts; 5.3 N2-Ethylidene-dG as a Biomarker of DNA Damage Resulting from Acetaldehyde Derived from Ethanol; 5.3.1 Experimental Studies of Acetaldehyde-DNA Adduct Formation from Alcohol Drinking in Humans; 5.3.2 Anatomical Considerations
000724603 5058_ $$a5.4 Why Are ALDH2-Deficient Individuals at Such Elevated Risk of Esophageal Cancer from Drinking Alcohol?5.5 Is There a "Carcinogenic" Level of Acetaldehyde?; 5.6 Summary and Conclusions; References; Chapter 6: The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis; 6.1 Introduction; 6.2 Health Statistics of ALD; 6.3 Prevalence of Iron Overload in ALD; 6.4 Iron Toxicity and Carcinogenesis; 6.5 Mechanism of Iron Overload; 6.6 Systemic Regulation; 6.7 Cellular Iron Regulation; 6.8 Redox Regulation of Iron Metabolism; 6.9 Non-hepatic Causes of Alcohol-Mediated Iron Overload
000724603 506__ $$aAccess limited to authorized users.
000724603 520__ $$aThis proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer, cell signaling and cancer, stem cells, biomarkers and metabolomics, aerodigestive cancers, cancer and the immune system, and more. In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated and this volume gives a comprehensive overview of these advancements.
000724603 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed February 17, 2015).
000724603 650_0 $$aAlcohol$$xCarcinogenicity.
000724603 7001_ $$aVasiliou, Vasilis,$$eeditor.
000724603 7001_ $$aZakhari, Samir,$$eeditor.
000724603 7001_ $$aSeitz, H. K.$$q(Helmut Karl),$$d1950-$$eeditor.
000724603 7001_ $$aHoek, Jan B.,$$eeditor.
000724603 77608 $$iPrint version:$$z9783319096131
000724603 830_0 $$aAdvances in experimental medicine and biology ;$$v815.
000724603 852__ $$bebk
000724603 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-319-09614-8$$zOnline Access$$91397441.1
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