Translational research methods for diabetes, obesity and cardiometabolic drug development [electronic resource] : a focus on early phase clinical studies /dc Andrew J. Krentz, Lutz Heinemann, Marcu Hompesch, editors.

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Translational research methods for diabetes, obesity and cardiometabolic drug development [electronic resource] : a focus on early phase clinical studies /dc Andrew J. Krentz, Lutz Heinemann, Marcu Hompesch, editors.

9781447149200 electronic book
1447149203 electronic book
9781447149194

London ; New York : Springer, [2015]

English

1 online resource

10.1007/978-1-4471-4920-0 doi

RM301.25

615.19

This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Includes bibliographical references and index.

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Online resource; title from PDF title page (viewed Dec. 15, 2014).

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