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000724654 019__ $$a908041689$$a908082959
000724654 020__ $$a9781493920532$$qelectronic book
000724654 020__ $$a1493920537$$qelectronic book
000724654 020__ $$z9781493920525
000724654 035__ $$aSP(OCoLC)ocn897377293
000724654 035__ $$aSP(OCoLC)897377293$$z(OCoLC)908041689$$z(OCoLC)908082959
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000724654 050_4 $$aQP606.P78$$bR43 2015eb
000724654 08204 $$a572.6$$223
000724654 24500 $$aReceptor tyrosine kinases$$h[electronic resource] :$$bstructure, functions and role in human disease /$$cDeric L. Wheeler, Yosef Yarden, editors.
000724654 264_1 $$aNew York :$$bHumana Press,$$c2015.
000724654 300__ $$a1 online resource (xvii, 440 pages) :$$billustrations (some color)
000724654 336__ $$atext$$btxt$$2rdacontent
000724654 337__ $$acomputer$$bc$$2rdamedia
000724654 338__ $$aonline resource$$bcr$$2rdacarrier
000724654 500__ $$aIncludes index.
000724654 504__ $$aIncludes bibliographical references and index.
000724654 5050_ $$aPreface; About the Editors; Contents; Chapter 1: The Eukaryotic Protein Kinase Superfamily and the Emergence of Receptor Tyrosine Kinases; 1.1 The Human Kinome; 1.2 Protein Kinases and Human Disease; 1.3 Kinome Evolution; 1.4 The Genesis of Receptor Tyrosine Kinases; 1.5 Evolution of the Receptor Tyrosine Kinases; 1.6 The Development of Ligand-Regulated RTK Activity; 1.7 Coda; References; Chapter 2: Evolution of Receptor Tyrosine Kinases; 2.1 Introduction; 2.2 The EGF Receptor Family; 2.3 The Insulin Receptor Family; 2.4 The FGF Receptor Family; 2.5 The VEGF Receptor Family
000724654 5058_ $$a2.6 The PDGF Receptor Family2.7 The NTRK Family; 2.8 The TAM Receptor Family; 2.9 The DDR Family; 2.10 The EPH Receptor Family; 2.11 The ROR, TIE, MET, and ALK Receptor Families; 2.12 MUSK, PTK7, RET, ROS, and RYK; 2.13 The NOK Family; 2.14 Evolution of RTK Ligands; 2.15 EGFR Ligands; 2.16 The FGF Family; 2.17 The PDGF/VEGF Family of Growth Factors; 2.18 Conclusions; References; Chapter 3: RTKs in Invertebrates: Lessons in Signal Transduction; 3.1 Families of RTKs in Drosophila; 3.2 Linear vs. Branched RTK Signaling Pathways; 3.3 Spatial and Temporal Features of RTK Signaling
000724654 5058_ $$a3.4 Restricting the Range of RTK Signaling3.5 Concept of "Ratchet-Like" Signal Expansion; 3.6 Integral vs. Auxiliary Elements in the Signaling Pathway of RTKs; 3.7 Cell Biology of RTK Signaling During Development; 3.8 Transcriptional Output of RTK Pathways; 3.9 Overlap Between RTKs and Other Signaling Pathways; References; Chapter 4: Receptor Tyrosine Kinase Signal Transduction and the Molecular Basis of Signalling Specificity; 4.1 Introduction; 4.2 RTKs Assemble into Dimeric Allosteric Enzymes; 4.3 Cooperative Interactions in Ligand Binding to RTKs and Other Surface Receptors
000724654 5058_ $$a4.4 Allosteric Activation of RTKs Intracellular Kinase Domains4.5 RTK Intracellular Signalling Pathways; 4.6 The Paradox of Signalling Specificity; 4.7 Systems Biology of Combinatorial Signalling; 4.8 Cell Cycle Regulation by RTKs; 4.9 Regulation of Apoptosis by RTKs; 4.10 Conclusion and Perspectives; References; Chapter 5: Nuclear Functions of Receptor Tyrosine Kinases; 5.1 Introduction; 5.2 EGFR Family; 5.2.1 Discovery of Nuclear EGFR Family; 5.3 Functions of EGFR Family in the Nucleus; 5.3.1 EGFR/ErbB-1; 5.3.2 ErbB-2/HER-2; 5.3.3 ErbB-3; 5.3.4 ErbB-4; 5.4 FGFR Family; 5.4.1 FGFR1
000724654 5058_ $$a5.4.2 FGFR25.4.3 FGFR3 and FGFR4; 5.5 VEGFR Family; 5.5.1 VEGFR-1; 5.5.2 VEGFR-2; 5.6 Other Receptor Tyrosine Kinases; 5.6.1 Insulin Receptor Family; 5.6.1.1 Insulin Receptor; 5.6.1.2 Insulin-Like Growth Factor I Receptor; 5.6.2 HGF Receptor Family; 5.6.3 ROR; 5.6.4 Eph Receptors; 5.6.5 Ryk; 5.6.6 Trk; 5.6.7 Mer; 5.6.8 PDGFR-Alpha; 5.7 Summary; 5.8 Conclusion; References; Chapter 6: Computational and Modeling Aspects of RTK Networks; 6.1 Introduction; 6.2 Topic 1: The Multilayered ERBB Signaling Network; 6.2.1 The Input Layer; 6.2.1.1 Combinatorial Complexity of the Input Layer
000724654 506__ $$aAccess limited to authorized users.
000724654 520__ $$aReceptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade they became the Number 1 targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in human, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able.
000724654 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed January 29, 2015).
000724654 650_0 $$aProtein-tyrosine kinase.
000724654 7001_ $$aWheeler, Deric L.,$$eeditor.
000724654 7001_ $$aYarden, Y.$$q(Yosef),$$eeditor.
000724654 77608 $$iPrint version:$$tReceptor tyrosine kinases : structure, functions and role in human disease.$$dNew York : Humana Press, [2015]$$z9781493920525$$w(DLC)18334947
000724654 852__ $$bebk
000724654 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-2053-2$$zOnline Access$$91397441.1
000724654 909CO $$ooai:library.usi.edu:724654$$pGLOBAL_SET
000724654 980__ $$aEBOOK
000724654 980__ $$aBIB
000724654 982__ $$aEbook
000724654 983__ $$aOnline
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